6-ForMylindolo[3,2-b]carbazole
Synonym(s):5,11-Dihydro-indolo[3,2-b]carbazole-6-carboxaldehyde;6-Formylindolo[3,2-b]carbazole
- CAS NO.:172922-91-7
- Empirical Formula: C19H12N2O
- Molecular Weight: 284.31
- MDL number: MFCD09879259
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is 6-ForMylindolo[3,2-b]carbazole?
Description
6-Formylindolo(3,2-b)carbazole (FICZ) (172922-91-7) is a very potent (Kd?= 0.07 nM) endogenous ligand for the aryl hydrocarbon receptor (AhR).1,2
The Uses of 6-ForMylindolo[3,2-b]carbazole
6-Formylindolo[3,2-b]carbazole is a tryptophan photoproduct, suppresses pulmonary eosinophilia and Th2-type cytokine production in a mouse model of ovalbumin-induced allergic asthma.
What are the applications of Application
6-Formylindolo[3,2-b]carbazole is a high affinity aryl hydrocarbon receptor ligand
Biochem/physiol Actions
FICZ is a potent high affinity ligand of the aryl hydrocarbon receptor (AhR), which is a ligand-activated transcription factor that activates the expression of aromatic hydrocarbon metabolizing enzyme genes such as the CYP1A1 gene and has also been shown to have multiple additional roles in cell-cycle regulation, development and maturation of many tissues, control of inflammation, and immune response. FICZ is a photoproduct of tryptophan and is believed to be an endogenous AhR ligand. It is extremely potent, with a Kd value of 0.07 nM.
storage
Store at -20°C
References
1) Rannung?et al. (1987)?Certain photooxidized derivatives of tryptophan bind with very high affinity to the Ah receptor and are likely to be endogenous signal substances; J. Biol. Chem.,?262?15422 .2) Wincent?et al. (2009)?The Suggested Physiologic Aryl Hydrocarbon Receptor Activator and Cytochrome P4501 Substrate 6-Formylindolo[3,2-b}carbazole is Present in Humans; J. Biol. Chem.,?284?2690
Properties of 6-ForMylindolo[3,2-b]carbazole
Boiling point: | 630.3±35.0 °C(Predicted) |
Density | 1.463±0.06 g/cm3(Predicted) |
storage temp. | -20°C |
solubility | Soluble in DMSO (up to 10 mg/ml). |
pka | 15.66±0.30(Predicted) |
form | powder |
color | yellow to orange |
Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
Safety information for 6-ForMylindolo[3,2-b]carbazole
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral |
Computed Descriptors for 6-ForMylindolo[3,2-b]carbazole
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