6-Chlorohexanol

Synonym(s):1-Chloro-6-hydroxyhexane;Hexamethylene chlorohydrin

CAS NO.：2009-83-8
Empirical Formula: C6H13ClO
Molecular Weight: 136.62
MDL number: MFCD00002984
EINECS: 217-925-2
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-21 22:41:43

What is 6-Chlorohexanol?

Chemical properties

clear colorless to pale yellow liquid

The Uses of 6-Chlorohexanol

6-Chloro-1-hexanol is used in the preparation of its corresponding bromide by reaction with sodium bromide using N,N-dimethylformamide and dibromomethane (2:1) as a solvent. It is utilized in the selective elimination of 6-chloro-1-hexene from esters of 6-chloro-1-hexanol.

Preparation

6-Chlorohexanol is obtained from the reaction of 1,6-Hexanediol with hydrochloric acid.

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 3, p. 446, 1955
Tetrahedron Letters, 36, p. 3161, 1995 DOI: 10.1016/0040-4039(95)00501-3

Properties of 6-Chlorohexanol

Melting point:	102 °C
Boiling point:	108-112 °C14 mm Hg(lit.)
Density	1.024 g/mL at 25 °C(lit.)
vapor pressure	1.066hPa at 21.1℃
refractive index	n20/D 1.456(lit.)
Flash point:	210 °F
storage temp.	Sealed in dry,Room Temperature
solubility	Soluble in dimethylformamide.
form	Liquid
pka	15.17±0.10(Predicted)
Specific Gravity	1.024
color	Clear colorless to pale yellow
Water Solubility	11.3g/L at 20℃
BRN	1697307
CAS DataBase Reference	2009-83-8(CAS DataBase Reference)
NIST Chemistry Reference	1-Hexanol, 6-chloro-(2009-83-8)
EPA Substance Registry System	1-Hexanol, 6-chloro- (2009-83-8)

Safety information for 6-Chlorohexanol

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.