2-Chloro-6-methylpyridine

Synonym(s):6-Chloro-2-picoline

CAS NO.：18368-63-3
Empirical Formula: C6H6ClN
Molecular Weight: 127.57
MDL number: MFCD00006245
EINECS: 242-241-6
SAFETY DATA SHEET (SDS)
Update Date: 2024-05-14 14:43:47

What is 2-Chloro-6-methylpyridine?

Description

2-Chloro-6-methylpyridine (2C6MP) is a strong inhibitor of methane monooxygenase, a key enzyme in the aerobic oxidation of methane (CH4). It belongs to the pesticide nitropyridine group of compounds. Studies have shown that 2C6MP has the least effect on CH4 oxidation at concentrations of 0.1 mM and 1 mM, but at a concentration of 10 mM, 2C6MP inhibits CH4 oxidation for >20 months. Low concentrations of 2C6MP did not inhibit Methylophilaceae, while high concentrations of 2C6MP inhibited Methylophilaceae by only 7.8 ± 1.1%^[1].

Chemical properties

Light yellow liquid

The Uses of 2-Chloro-6-methylpyridine

2-Chloro-6-methylpyridine has been used for experimental FTIR and FT-Raman spectroscopic analyses, as well as for conformational studies.

References

[1] E. O’LOUGHLIN. Inhibition of Microbial Methane Oxidation by 2-Chloro-6-Methylpyridine[J]. bioRxiv?: the preprint server for biology, 2022. DOI:10.1101/2022.10.13.512149.

Properties of 2-Chloro-6-methylpyridine

Boiling point:	64-68 °C10 mm Hg(lit.)
Density	1.167 g/mL at 25 °C(lit.)
refractive index	n20/D 1.527(lit.)
Flash point:	165 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
form	Liquid
pka	1.10±0.10(Predicted)
Specific Gravity	1.167
color	Clear colorless to light yellow
BRN	107187
InChI	InChI=1S/C6H6ClN/c1-5-3-2-4-6(7)8-5/h2-4H,1H3
CAS DataBase Reference	18368-63-3(CAS DataBase Reference)
NIST Chemistry Reference	2-Cl-6-(CH3)-pyridine(18368-63-3)
EPA Substance Registry System	Pyridine, 2-chloro-6-methyl- (18368-63-3)

Safety information for 2-Chloro-6-methylpyridine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.