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HomeProduct name list6-(Bromomethyl)-2,4-pteridinediamine hydrobromide

6-(Bromomethyl)-2,4-pteridinediamine hydrobromide

  • CAS NO.:52853-40-4
  • Empirical Formula: C7H8Br2N6
  • Molecular Weight: 335.99
  • MDL number: MFCD09833976
  • EINECS: 692-499-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-09-14 17:34:31
6-(Bromomethyl)-2,4-pteridinediamine hydrobromide Structural

What is 6-(Bromomethyl)-2,4-pteridinediamine hydrobromide?

Description

6-(Bromomethyl)-2,4-pteridinediamine hydrobromide is a potent inhibitor of the enzyme nitroaldolase (EC 1.2.1.22) and has been shown to inhibit cell growth in murine leukemia cells. This reaction is mediated by the addition of bromide to isobutyl esters, leading to a benzyl ester intermediate which undergoes an electrophilic attack on nitroaldolase. The mechanism of action for this drug involves the inhibition of membrane transport and chloride ion influx, which are necessary for the proliferation of tumor cells. 6-(Bromomethyl)-2,4-pteridinediamine hydrobromide also inhibits DNA synthesis through its effects on thymidylate synthase, preventing nucleotide production from thymine and dihydrofolate reductase activity.

Chemical properties

Light Brown Solid

The Uses of 6-(Bromomethyl)-2,4-pteridinediamine hydrobromide

6-(Bromomethyl)-2,4-pteridinediamine hydrobromide can be used as organic synthesis intermediate and pharmaceutical intermediate.

What are the applications of Application

6-(Bromomethyl)-2,4-pteridinediamine Hydrobromide (Technical Grade) is a useful research chemical used in the preparation of novel methotrexate derivatives as antirheumatic agents as well as the preparation of pteridine reductase inhibitors.

Properties of 6-(Bromomethyl)-2,4-pteridinediamine hydrobromide

Melting point: >195°C (dec.)
storage temp.  -20°C Freezer
solubility  DMSO (Slightly), Methanol (Slightly)
form  Solid
color  Light Brown to Brown
InChI InChI=1S/C7H7BrN6.BrH/c8-1-3-2-11-6-4(12-3)5(9)13-7(10)14-6;/h2H,1H2,(H4,9,10,11,13,14);1H

Safety information for 6-(Bromomethyl)-2,4-pteridinediamine hydrobromide

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 6-(Bromomethyl)-2,4-pteridinediamine hydrobromide

InChIKey KMQIBGKVZDBGAH-UHFFFAOYSA-N
SMILES NC1=NC(N)=NC2=NC=C(CBr)N=C12.Br

Abamectin manufacturer

PSN Medicare Private Limited

1Y
Phone:+91-7702388996
Whatsapp: +91-7702388996
product: 52853-40-4 2,4-Diamino-6-(bromomethyl)-pteridine hydrobromide 99%
Inquiry

ALS INDIA LIFE SCIENCES

1Y
Phone:+91-8977036379
Whatsapp: +91 8008166674
product: 52853-40-4 98%
Inquiry

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