5,11-Dihydropyrido[2,3-b][1,4]benzodiazepin-6-one
- CAS NO.:885-70-1
- Empirical Formula: C12H9N3O
- Molecular Weight: 211.22
- MDL number: MFCD00190169
- EINECS: 212-944-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is 5,11-Dihydropyrido[2,3-b][1,4]benzodiazepin-6-one?
The Uses of 5,11-Dihydropyrido[2,3-b][1,4]benzodiazepin-6-one
5,11-Dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one, can be used in the synthesis of fluorescent pirenzepine derivatives, used as potential bitopic ligands of the Human M1 Muscarinic receptor.
Synthesis
In a 1000 ml reaction flask,Add 600 ml of butanol,100 g of 2-amino-N- (2-chloropyridyl-3-yl) benzamide,2 ml of concentrated sulfuric acid,The reaction was refluxed for 3 hours at a reaction temperature of 80 ?? C,Cooled to room temperature,filter,Washed with acetone,50-60 ?? C in vacuo to give 98 g of a pale yellow solid product,Yield 98percent, purity 99percent.
Properties of 5,11-Dihydropyrido[2,3-b][1,4]benzodiazepin-6-one
Melting point: | 292-293℃ |
Boiling point: | 336℃ |
Density | 1.275 |
Flash point: | 157℃ |
storage temp. | Refrigerator, under inert atmosphere |
solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
form | Solid |
pka | 11.58±0.20(Predicted) |
color | Light Beige to Beige |
Safety information for 5,11-Dihydropyrido[2,3-b][1,4]benzodiazepin-6-one
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H332:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 5,11-Dihydropyrido[2,3-b][1,4]benzodiazepin-6-one
New Products
(R)-(-)-2-Amino-1-propanol Tetrahydro-4H-pyran-4-one Bromine 99.5% AR (4 x 500ml) Linseed Oil Extrapure Hydrogen Sulphide Solution Oxalic Acid 0.05 mol/L (0.01N) Solution EDTA 0.1 mol/L (0.2N) for 1000 ml Ferroin 0.025M Solution AR 1,2,3,4-Tetrahydrocarbazol-4-one 4-Hydroxy Carbazole Amino Salicylic Acid. U.S.P. 2 – Methoxy – 5- Sulfamoyl Benzoic acid Acetone Isobutryl oxime ester Sodium Amino Salicylate Dihydrate (PAS Sodium) IP/BP/USP/EP Aloe vera extract 200x Withania somnifera (Ashwagandha Extract) Citrus bioflavonoids Extract Spirulina (Arthrospira platensis) Powder Trikatu Extract Thymol Oil Ethyl 3-(Pyridin-2-Ylamino)Propanoate Bilastine -IP/BP/ Cypermethric Acid Chloride 5-NitrosalicylaldehydeRelated products of tetrahydrofuran
Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
AF-DX 384, [2,3-DIPROPYLAMINO-3H]-
PIRENZEPINE, [N-METHYL-3H]-
11-[[2-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE
tripitramine
Pirenzepine hydrochloride
6H-Pyrido(2,3-b)(1,4)benzodiazepin-6-one, 5,11-dihydro-11-(1H-imidazol -1-ylacetyl)-, hydrate
5,11-Dihydropyrido[2,3-b][1,4]benzodiazepin-6-one
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