5,11-Dihydropyrido[2,3-b][1,4]benzodiazepin-6-one
- CAS NO.：885-70-1
- Empirical Formula: C12H9N3O
- Molecular Weight: 211.22
- MDL number: MFCD00190169
- EINECS: 212-944-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
![5,11-Dihydropyrido[2,3-b][1,4]benzodiazepin-6-one Structural](https://img.chemicalbook.in/CAS/GIF/885-70-1.gif)
What is 5,11-Dihydropyrido[2,3-b][1,4]benzodiazepin-6-one?
The Uses of 5,11-Dihydropyrido[2,3-b][1,4]benzodiazepin-6-one
5,11-Dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one, can be used in the synthesis of fluorescent pirenzepine derivatives, used as potential bitopic ligands of the Human M1 Muscarinic receptor.
Synthesis
In a 1000 ml reaction flask,Add 600 ml of butanol,100 g of 2-amino-N- (2-chloropyridyl-3-yl) benzamide,2 ml of concentrated sulfuric acid,The reaction was refluxed for 3 hours at a reaction temperature of 80 ?? C,Cooled to room temperature,filter,Washed with acetone,50-60 ?? C in vacuo to give 98 g of a pale yellow solid product,Yield 98percent, purity 99percent.
Properties of 5,11-Dihydropyrido[2,3-b][1,4]benzodiazepin-6-one
| Melting point: | 292-293℃ |
| Boiling point: | 336℃ |
| Density | 1.275 |
| Flash point: | 157℃ |
| storage temp. | Refrigerator, under inert atmosphere |
| solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
| form | Solid |
| pka | 11.58±0.20(Predicted) |
| color | Light Beige to Beige |
Safety information for 5,11-Dihydropyrido[2,3-b][1,4]benzodiazepin-6-one
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H332:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 5,11-Dihydropyrido[2,3-b][1,4]benzodiazepin-6-one
New Products
Tubulysin C Tubulysin I Tubulysin M Tubulysin F Tubulysin B Potassium HMDS (1.0 M in THF) Diethyl Aluminium Cyanide (1.0 M in Toluene) 3-Aminocyclobutanone hydrochloride 4,4-DIFLUOROPIPERIDINE 2H-Pyran, 4-ethynyltetrahydro- 3-METHYLAZETIDIN-3-OL HYDROCHLORIDE 4,4-DIFLUOROCYCLOHEXANAMINE 4-(Benzyloxy)-3-bromophenylacetic Acid Imeglimin Hydrochloride IH 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Fuel shell Magnesium Trisilicate Latanoprostene Bunod Lubiprostone Flame Retardant Zinc Borate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonateRelated products of tetrahydrofuran
![AF-DX 384, [2,3-DIPROPYLAMINO-3H]-](https://img.chemicalbook.in/StructureFile/ChemBookStructure2/GIF/CB4690049.gif)
![PIRENZEPINE, [N-METHYL-3H]-](https://img.chemicalbook.in/StructureFile/ChemBookStructure2/GIF/CB4356143.gif)
![11-[[2-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE](https://img.chemicalbook.in/CAS/GIF/102394-31-0.gif)
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