5'-O-(Dimethoxytrityl)-5-iodo-2'-deoxyuridine
- CAS NO.：104375-88-4
- Empirical Formula: C30H29IN2O7
- Molecular Weight: 656.46
- MDL number: MFCD01631069
- EINECS: 2017-001-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 16:48:35
What is 5'-O-(Dimethoxytrityl)-5-iodo-2'-deoxyuridine?
Description
5'-O-(Dimethoxytrityl)-5-iodo-2'-deoxyuridine (2'-Deoxy-5'-O-DMT-5-iodouridine) is an intercalating agent that binds to DNA and RNA. It can be used as a probe for the detection of specific sequences in human cells. The fluorophore attached to the molecule allows it to be detected by fluorescence microscopy, while the chromophore is responsible for its ability to emit light at a wavelength of 535 nm. 2'-Deoxy-5'-O-DMT-5-iodouridine has been shown to enhance nucleotide excision repair and increase the sensitivity of cancer cells to chemotherapy drugs such as cisplatin. The molecule can also be used as a fluorescent protein marker in her-2 gene amplification and overexpression studies.
The Uses of 5'-O-(Dimethoxytrityl)-5-iodo-2'-deoxyuridine
2’-Deoxy-5’-O-DMT-5-iodouridine is a modified oligonucleotides designed for use in genetic analysis and RNA detection.
Properties of 5'-O-(Dimethoxytrityl)-5-iodo-2'-deoxyuridine
| Melting point: | >128 °C (decomp) |
| Density | 1.60±0.1 g/cm3(Predicted) |
| pka | 7.94±0.10(Predicted) |
Safety information for 5'-O-(Dimethoxytrityl)-5-iodo-2'-deoxyuridine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 5'-O-(Dimethoxytrityl)-5-iodo-2'-deoxyuridine
| InChIKey | RLDUYGSOCGOJTP-SKDNVIITNA-N |
| SMILES | C(OC[C@@H]1[C@@H](O)C[C@H](N2C=C(C(=O)NC2=O)I)O1)(C1C=CC=CC=1)(C1=CC=C(OC)C=C1)C1=CC=C(OC)C=C1 |&1:3,4,7,r| |
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