DMT-2'-Fluoro-dG(Ib) Phosphoramidite
- CAS NO.：144089-97-4
- Empirical Formula: C44H53FN7O8P
- Molecular Weight: 857.91
- MDL number: MFCD12912415
- Update Date: 2024-10-23 13:36:13
What is DMT-2'-Fluoro-dG(Ib) Phosphoramidite?
Description
DMT-2'-Fluoro-dG(Ib) Phosphoramidite is a 2′Fluoro phosphoramidite that is used to synthesize oligonucleotides that are more thermally stable and provide increased nuclease resistance.
The Uses of DMT-2'-Fluoro-dG(Ib) Phosphoramidite
DMT-2''Fluoro-DG(IB) amidite (CAS# 144089-97-4) is a nucleoside used in the preparation of cyclic dinucleotide compounds, and in the preparation of 4''-C-methoxy-2''-deoxy-2''-fluoro modified ribonucleotides, which improve metabolic stability and elicit efficient RNAi-mediated gene silencing.
Definition
The key features of DMT-2'-Fluoro-dG(Ib) Phosphoramidite include, Can be employed together with DNA or RNA phosphoramidites Recommended deprotection conditions are 8 hours at 55 °C using concentrated ammonia solution, or with AMA for 10 minutes at 65 °C Synthesis of 2′Fluoro oligonucleotides is similar to standard DNA synthesis but requires an elongated coupling time (recommended is 3 minutes compared to 90 seconds for DNA monomers) Consistent lot-to-lot high purity and performance Manufactured under a certified ISO 9001 quality system.
Properties of DMT-2'-Fluoro-dG(Ib) Phosphoramidite
| storage temp. | -20°C |
| solubility | DMSO : 100 mg/mL (116.56 mM) |
| form | powder |
| pka | 9.16±0.20(Predicted) |
| color | white to off-white |
Safety information for DMT-2'-Fluoro-dG(Ib) Phosphoramidite
Computed Descriptors for DMT-2'-Fluoro-dG(Ib) Phosphoramidite
| InChIKey | CFFUQMXILRDKMM-QPYLYBSMNA-N |
| SMILES | C(NC1=NC(=O)C2=C(N1)N([C@H]1[C@H](F)[C@H](OP(OCC)N(C(C)C)C(C#N)(C)C)[C@@H](COC(C3=CC=C(OC)C=C3)(C3=CC=C(OC)C=C3)C3=CC=CC=C3)O1)C=N2)(=O)C(C)C |&1:10,11,13,28,r| |
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Innovassynth Technologies (I) Ltd.
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