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HomeProduct name list5-METHOXYQUINOLIN-8-AMINE

5-METHOXYQUINOLIN-8-AMINE

Synonym(s):5-Methoxy-8-quinolinamine;Chen Auxilliary;Gong Chen Auxiliary;MQ;MQ Auxiliary

5-METHOXYQUINOLIN-8-AMINE Structural

What is 5-METHOXYQUINOLIN-8-AMINE?

The Uses of 5-METHOXYQUINOLIN-8-AMINE

The Chen auxiliary was reported to be an effective directing group in the synthesis of pyrrolidones from assisting in the activation of C(sp3)-H bonds and can be readily installed through amide bond formation and removed through mild conditions using CAN at room temperature.

General Description

8-Amino-5-methoxyquinoline is a substituted quinoline derivative that can be prepared using 5-chloro-2-nitroaniline as a starting material. It can act as an easily removable directing group and also mediate C-H activation. These properties have been useful for synthesizing isomeric dibenzoxazepinones and complex pyrrolidinones from compounds containing 8-amino-5-methoxyquinoline moiety.

Properties of 5-METHOXYQUINOLIN-8-AMINE

Melting point: 90-95°C
Boiling point: 355.7±27.0 °C(Predicted)
Density  1.217±0.06 g/cm3(Predicted)
storage temp.  under inert gas (nitrogen or Argon) at 2–8 °C
pka 3.98±0.12(Predicted)
form  powder

Safety information for 5-METHOXYQUINOLIN-8-AMINE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 5-METHOXYQUINOLIN-8-AMINE

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