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HomeProduct name list5-Hydroxyindole-2-carboxylic acid

5-Hydroxyindole-2-carboxylic acid

Synonym(s):NSC 117338

  • CAS NO.:21598-06-1
  • Empirical Formula: C9H7NO3
  • Molecular Weight: 177.16
  • MDL number: MFCD00005615
  • EINECS: 244-468-6
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-05-04 17:34:35
5-Hydroxyindole-2-carboxylic acid Structural

What is 5-Hydroxyindole-2-carboxylic acid?

Chemical properties

light yellow to beige crystalline powder

The Uses of 5-Hydroxyindole-2-carboxylic acid

5-Hydroxyindole-2-carboxylic acid was used in HPLC-amperometric detection of serotonin in plasma, platelets and urine.

The Uses of 5-Hydroxyindole-2-carboxylic acid

• ;Reactant for preparation of indole C5-O-substituted seco-cyclopropylindole analogs as potential anticancer agents• ;Reactant for microwave combinatorial synthesis of indolic arylpiperazine derivatives as ligands for 5-HT1A, 5-HT2A, and 5-HT2C receptors1• ;Reactant for preparation of melanins as novel nature-inspired radioprotectors2• ;Reactant for preparation of 5-Hydroxyindole-2-carboxylic acid amides as histamine-3 receptor inverse agonists for the treatment of obesity3• ;Reactant for preparation of conformationally constrained peptidomimetic inhibitors of signal

The Uses of 5-Hydroxyindole-2-carboxylic acid

A competitive antagonist of potentiation by glycine at the N-methyl-D-aspartate receptors that have been linked to neuronal death, assiciated to such afflictions as stroke and epilepsy.

Definition

ChEBI: 5-Hydroxyindole-2-carboxylic acid is an indolyl carboxylic acid.

General Description

5-Hydroxyindole-2-carboxylic acid on oxidation with KMnO4 yields pyrrole-2,3,5-tricarboxylic acid.

Properties of 5-Hydroxyindole-2-carboxylic acid

Melting point: 249 °C (dec.) (lit.)
Boiling point: 309.06°C (rough estimate)
Density  1.3312 (rough estimate)
refractive index  1.5200 (estimate)
storage temp.  Sealed in dry,2-8°C
solubility  chloroform/ethanol (1:1): soluble50mg/mL, clear to slightly hazy, yellow to brown
pka 4.38±0.30(Predicted)
form  Fuming Liquid
color  Clear colorless to slightly yellow
BRN  153214
CAS DataBase Reference 21598-06-1(CAS DataBase Reference)

Safety information for 5-Hydroxyindole-2-carboxylic acid

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405:Store locked up.

Computed Descriptors for 5-Hydroxyindole-2-carboxylic acid

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