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EXO1

EXO1 Structural

What is EXO1?

The Uses of EXO1

Exo1 is used in the synthetic preparation of tricyclic heterocyclic compounds as antagonists of tachykinin receptor (substance P receptor) for prevention and/or treatment of substance P-related diseases.

What are the applications of Application

Exo1 is an inhibitor of protein traffic emanating from the ER which acts by inducing the fast collapse of the Golgi

Definition

ChEBI: 2-[[(4-fluorophenyl)-oxomethyl]amino]benzoic acid methyl ester is a member of benzamides.

Biological Activity

Reversible inhibitor of vesicular trafficking between endoplasmic reticulum and Golgi apparatus. Modifies Golgi ADP-ribosylation factor (ARF)1 GTPase activity and inhibits exocytosis (IC 50 ~ 20 mM). Has similar, but not identical, action to brefeldin A (1,6,7,8,9,11ab,12,13,14,14aa-Decahydro-1b,13a-dihydroxy-6b-methyl-4H-cyclopent(f)oxacyclotridecin-4-one ).

Properties of EXO1

Melting point: 132-134℃
Boiling point: 415.2±45.0 °C(Predicted)
Density  1.246±0.06 g/cm3(Predicted)
storage temp.  Store at RT
solubility  DMSO: 19 mg/mL, soluble
form  solid
pka -1.09±0.10(Predicted)

Safety information for EXO1

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H312:Acute toxicity,dermal
H332:Acute toxicity,inhalation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P321:Specific treatment (see … on this label).
P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

Computed Descriptors for EXO1

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