5-Fluoroindole
Synonym(s):NSC 88613
- CAS NO.：399-52-0
- Empirical Formula: C8H6FN
- Molecular Weight: 135.14
- MDL number: MFCD00005671
- EINECS: 206-917-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is 5-Fluoroindole?
Chemical properties
off-white crystalline powder
The Uses of 5-Fluoroindole
• ;Reactant for preparation of 5-HT6 receptor ligands1• ;Reactant for preparation of tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators2• ;Reactant for preparation of antitumor agents3• ;Reactant for preparation of antibacterial agents4• ;Reactant for preparation of immunosuppressive agents5• ;Reactant for preparation of Sodium-Dependent Glucose Co-transporter 2 (SGLT2) Inhibitors for the Management of Hyperglycemia in Diabetes6• ;Reactant for preparation of Myeloperoxidase Inhibitors7• ;Reactant fo
The Uses of 5-Fluoroindole
5-Fluoroindole is a reactant used in various syntheses. It was used in the synthesis of Spirotetrahydro β-Carbolines (Spiroindolones), which is a new class of potent and orally efficacious compounds for the treatment of malaria. 5-Fluoroindole was also a reactant in direct indole and pyrrole couplings to carbonyl compound in total synthesis of Acremoauxin A and Oxazinin 3.
The Uses of 5-Fluoroindole
- Reactant for preparation of 5-HT6 receptor ligands
- Reactant for preparation of tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators
- Reactant for preparation of antitumor agents
- Reactant for preparation of antibacterial agents
- Reactant for preparation of immunosuppressive agents
- Reactant for preparation of Sodium-Dependent Glucose Co-transporter 2 (SGLT2) Inhibitors for the Management of Hyperglycemia in Diabetes
- Reactant for preparation of Myeloperoxidase Inhibitors
- Reactant for preparation of Potent Selective Serotonin Reuptake Inhibitors
Definition
ChEBI: An organofluorine compound that is the 5-fluoro derivative of indole.
Properties of 5-Fluoroindole
| Melting point: | 45-48 °C (lit.) |
| Boiling point: | 120 °C / 1mmHg |
| Density | 1.1203 (estimate) |
| Flash point: | >230 °F |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Crystalline Powder |
| pka | 16.16±0.30(Predicted) |
| color | Off-white |
| BRN | 112350 |
| CAS DataBase Reference | 399-52-0(CAS DataBase Reference) |
| NIST Chemistry Reference | 1H-indole, 5-fluoro-(399-52-0) |
Safety information for 5-Fluoroindole
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 5-Fluoroindole
Abamectin manufacturer
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Phone:+91-9704422000
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product: 399-52-0 5-Fluoro Indole 98%
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