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HomeProduct name list5-(Ethylthio)-1H-tetrazole

5-(Ethylthio)-1H-tetrazole

Synonym(s):ETT;OCTN1;SLC22A4;UT2H;5-(Ethylthio)-1H-tetrazole

  • CAS NO.:89797-68-2
  • Empirical Formula: C3H6N4S
  • Molecular Weight: 130.17
  • MDL number: MFCD00068733
  • EINECS: 000-000-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-08-21 22:41:43
5-(Ethylthio)-1H-tetrazole Structural

What is 5-(Ethylthio)-1H-tetrazole?

Chemical properties

White crystals

What are the applications of Application

5-(Ethylthio)-1H-tetrazole is used a powerful activator in DNA and RNA syntheses.

Preparation

5-(Ethylthio)-1H-Tetrazole is prepared from the corresponding alkyl thiocyanate and sodium azide through a [2?+?3] cycloaddition under phase transfer catalytic conditions (eq 1). The ratio of the solvent (water to toluene) as well as the reaction temperature are important factors in obtaining preparative yields of the alkylthiotetrazoles. 5-Ethylthio-1H-tetrazole has also been prepared using DMF as solvent albeit in much lower yield.
synthesis of 5-(Ethylthio)-1H-tetrazole

General Description

5-(Ethylthio)-1H-tetrazole (ETT) is an efficient activator, that activates nucleoside phosphoramidites towards condensation with a nucleoside to form dinucleoside phosphates during oligonucleotide synthesis.

Purification Methods

recrystallized from toluene.

Properties of 5-(Ethylthio)-1H-tetrazole

Melting point: 72-80 °C(lit.)
Boiling point: 81-82 °C
Density  0.786 g/mL at 25 °C
Flash point: 42 °F
storage temp.  2-8°C
solubility  soluble, clear, colorless
form  buffered aqueous solution
pka 3.89±0.10(Predicted)
color  solid white
CAS DataBase Reference 89797-68-2(CAS DataBase Reference)

Safety information for 5-(Ethylthio)-1H-tetrazole

Signal word Danger
Pictogram(s)
ghs
Flame
Flammables
GHS02
ghs
Corrosion
Corrosives
GHS05
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H225:Flammable liquids
H315:Skin corrosion/irritation
H318:Serious eye damage/eye irritation
Precautionary Statement Codes P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 5-(Ethylthio)-1H-tetrazole

InChIKey GONFBOIJNUKKST-UHFFFAOYSA-N

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