5'-DEOXYADENOSINE
Synonym(s):5′-dAdo
- CAS NO.：4754-39-6
- Empirical Formula: C10H13N5O3
- Molecular Weight: 251.24
- MDL number: MFCD00056003
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-31 18:15:48
What is 5'-DEOXYADENOSINE?
The Uses of 5'-DEOXYADENOSINE
5′-Deoxyadenosine has been used:
- as a standard in mass spectroscopy
- as an inhibitor for screening thymidine phosphorylase activity
- as a substrate in 5′-Deoxyadenosine deaminase (DadD) assay
What are the applications of Application
5′-Deoxyadenosine is an analog of adenosin, and an intermediate in the degradation reaction of S-adenosylmethionine.
Definition
ChEBI: A 5'-deoxyribonucleoside compound having adenosine as the nucleobase.
Biochem/physiol Actions
5′-Deoxyadenosine is a substrate for the enzyme methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase in microbes. 5′-Deoxyadenosine is a byproduct of cleavage of S-adenosylmethionine (SAM). High levels of 5′-Deoxyadenosine inhibits SAM dependent enzymes. It also inhibits biotin synthase (BioB) and lipoyl synthase (LipA) enzymes.
Properties of 5'-DEOXYADENOSINE
| Melting point: | 210-212 °C |
| Boiling point: | 595.0±60.0 °C(Predicted) |
| Density | 1.93±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:4): 0.20 mg/ml; DMSO: 15 mg/ml |
| form | A crystalline solid |
| pka | 13.29±0.70(Predicted) |
| color | White to off-white |
Safety information for 5'-DEOXYADENOSINE
Computed Descriptors for 5'-DEOXYADENOSINE
| InChIKey | XGYIMTFOTBMPFP-KQYNXXCUSA-N |
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