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HomeProduct name list5'-DEOXYADENOSINE

5'-DEOXYADENOSINE

Synonym(s):5′-dAdo

5'-DEOXYADENOSINE Structural

What is 5'-DEOXYADENOSINE?

The Uses of 5'-DEOXYADENOSINE

5′-Deoxyadenosine has been used:

  • as a standard in mass spectroscopy
  • as an inhibitor for screening thymidine phosphorylase activity
  • as a substrate in 5′-Deoxyadenosine deaminase (DadD) assay

What are the applications of Application

5′-Deoxyadenosine is an analog of adenosin, and an intermediate in the degradation reaction of S-adenosylmethionine.

Definition

ChEBI: A 5'-deoxyribonucleoside compound having adenosine as the nucleobase.

Biochem/physiol Actions

5′-Deoxyadenosine is a substrate for the enzyme methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase in microbes. 5′-Deoxyadenosine is a byproduct of cleavage of S-adenosylmethionine (SAM). High levels of 5′-Deoxyadenosine inhibits SAM dependent enzymes. It also inhibits biotin synthase (BioB) and lipoyl synthase (LipA) enzymes.

Properties of 5'-DEOXYADENOSINE

Melting point: 210-212 °C
Boiling point: 595.0±60.0 °C(Predicted)
Density  1.93±0.1 g/cm3(Predicted)
storage temp.  2-8°C
solubility  DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:4): 0.20 mg/ml; DMSO: 15 mg/ml
form  A crystalline solid
pka 13.29±0.70(Predicted)
color  White to off-white

Safety information for 5'-DEOXYADENOSINE

Computed Descriptors for 5'-DEOXYADENOSINE

InChIKey XGYIMTFOTBMPFP-KQYNXXCUSA-N

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