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HomeProduct name list5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL

5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL

  • CAS NO.:566-26-7
  • Empirical Formula: C27H46O2
  • Molecular Weight: 402.66
  • MDL number: MFCD00201416
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-13 18:13:23
5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL Structural

What is 5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL?

Description

7α-Hydroxycholesterol (566-26-7) is a metabolite resulting from the action of cholesterol 7α-hydroxylase on cholesterol. 7α-Hydroxycholesterol is the first intermediate and a rate limiting step in the major pathway for bile acid synthesis in humans.??A pro-inflammatory mediator which upregulates production of CCL2 and MMP9 in macrophages and may promote progression of atherosclerosis.2,3?Possible biomarker for cellular lipid peroxidation.4

Chemical properties

White Solid

The Uses of 5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL

Secondary metabolite of Cholesterol

The Uses of 5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL

Secondary metabolite of Cholesterol.

What are the applications of Application

7α-Hydroxy Cholesterol is a secondary metabolite of Cholesterol

Definition

ChEBI: The 7alpha-hydroxy derivative of cholesterol.

References

1) Duane and Javitt (2002),?Conversion of 7 alpha-hydroxycholesterol to bile acid in human subjects: is there an alternate pathway favoring cholic acid synthesis?; J. Lab. Clin. Med.,?139?109 2) Kim?et al.?(2015)?7α-Hydroxycholesterol induces inflammation by enhancing production of chemokine (C-C motif) ligand 2; Biochem. Biophys. Res. Commun.,?467?879 3) Kim?et al.?(2014)?27-Hydroxycholesterol and 7alpha-hydroxycholesterol trigger a sequence of events leading to migration of CCR5-expressing Th1 lymphocytes; Toxicol. Appl. Pharmacol.,?274?462 4) Saito and Noguchi (2014)?7-Hydroxycholesterol as a possible biomarker of cellular lipid peroxidation: difference between cellular and plasma lipid peroxidation; Biochem. Biophys. Res. Commun.,?446?741

Properties of 5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL

Melting point: 168-170°C
Boiling point: 515.3±38.0 °C(Predicted)
Density  1.03±0.1 g/cm3(Predicted)
storage temp.  Refrigerator
solubility  Soluble in DMSO or in Ethanol.
form  solid
pka 14.11±0.70(Predicted)
color  White or pale yellow
Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

Safety information for 5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL

Computed Descriptors for 5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL

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