5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL
- CAS NO.：566-26-7
- Empirical Formula: C27H46O2
- Molecular Weight: 402.66
- MDL number: MFCD00201416
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-09-04 16:42:00
What is 5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL?
Description
7α-Hydroxycholesterol (566-26-7) is a metabolite resulting from the action of cholesterol 7α-hydroxylase on cholesterol. 7α-Hydroxycholesterol is the first intermediate and a rate limiting step in the major pathway for bile acid synthesis in humans.??A pro-inflammatory mediator which upregulates production of CCL2 and MMP9 in macrophages and may promote progression of atherosclerosis.2,3?Possible biomarker for cellular lipid peroxidation.4
Chemical properties
White Solid
The Uses of 5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL
Secondary metabolite of Cholesterol
The Uses of 5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL
Secondary metabolite of Cholesterol.
What are the applications of Application
7α-Hydroxy Cholesterol is a secondary metabolite of Cholesterol
Definition
ChEBI: The 7alpha-hydroxy derivative of cholesterol.
References
1) Duane and Javitt (2002),?Conversion of 7 alpha-hydroxycholesterol to bile acid in human subjects: is there an alternate pathway favoring cholic acid synthesis?; J. Lab. Clin. Med.,?139?109 2) Kim?et al.?(2015)?7α-Hydroxycholesterol induces inflammation by enhancing production of chemokine (C-C motif) ligand 2; Biochem. Biophys. Res. Commun.,?467?879 3) Kim?et al.?(2014)?27-Hydroxycholesterol and 7alpha-hydroxycholesterol trigger a sequence of events leading to migration of CCR5-expressing Th1 lymphocytes; Toxicol. Appl. Pharmacol.,?274?462 4) Saito and Noguchi (2014)?7-Hydroxycholesterol as a possible biomarker of cellular lipid peroxidation: difference between cellular and plasma lipid peroxidation; Biochem. Biophys. Res. Commun.,?446?741
Properties of 5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL
| Melting point: | 168-170°C |
| Boiling point: | 515.3±38.0 °C(Predicted) |
| Density | 1.03±0.1 g/cm3(Predicted) |
| storage temp. | Refrigerator |
| solubility | Soluble in DMSO or in Ethanol. |
| form | solid |
| pka | 14.11±0.70(Predicted) |
| color | White or pale yellow |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
Safety information for 5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL
Computed Descriptors for 5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL
New Products
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