5-Chlorovaleryl chloride
Synonym(s):5-Chloropentanoyl chloride
- CAS NO.:1575-61-7
- Empirical Formula: C5H8Cl2O
- Molecular Weight: 155.02
- MDL number: MFCD00000758
- EINECS: 216-403-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-01-18 17:03:10
What is 5-Chlorovaleryl chloride?
Chemical properties
clear colourless to slightly yellow liquid
The Uses of 5-Chlorovaleryl chloride
5-Chlorovaleroyl chloride (5-CVC) has been used in the development and validation of a GC-FID method for the analysis of low level impurities present in 5-CVC. It has been used in the synthesis of anion-exchange resins by acylation of polystyrene/divinylbenzene and subsequent amination with trimethylamine. It is commonly used as alkylating agent in the synthesis of pharmaceutical intermediates and other specialty chemicals.
What are the applications of Application
5-Chlorovaleryl chloride is an important medicine and pesticide intermediate. It is pharmaceutically mainly for the manufacture of the medicine Cilostazole (Cilostazol) for anti-platelet aggregation, protection of vascular endothelial cells, and atherosclerosis.5-Chlorovaleryl Chloride is also for the production of paddy rice New-type wide-spectrum weedicide pyraclonil (Pyraclonil).
General Description
5-Chlorovaleroyl chloride is commonly used as alkylating agent in the synthesis of pharmaceutical intermediates and other specialty chemicals.
Flammability and Explosibility
Not classified
Synthesis
In the existing process, producing 5-Chlorovaleryl chloride using 1,4-dichlorobutane as raw material requires a three-step reaction. First, 1,4-dichlorobutane and sodium cyanide solution are combined to form 5-chlorovaleronitrile. Then, the prepared 5-chlorovaleronitrile is hydrolyzed in concentrated hydrochloric acid to form 5-chlorovaleric acid. Finally, 5-chlorovaleronitrile reacts with thionyl chloride to generate 5-chlorovaleryl chloride.
Properties of 5-Chlorovaleryl chloride
Boiling point: | 38-39 °C0.15 mm Hg(lit.) |
Density | 1.206 g/mL at 20 °C |
refractive index | n |
Flash point: | 195 °F |
storage temp. | Store below +30°C. |
solubility | Acetonitrile (Slightly), Chloroform (Sparingly) |
form | Liquid |
color | Clear colorless to slightly yellow |
Specific Gravity | 1.200 |
PH | <7 (H2O, 20℃) |
explosive limit | 2.0-10.2%(V) |
Water Solubility | reacts |
Sensitive | Moisture Sensitive |
BRN | 1745182 |
Stability: | Corrosive, Moisture Sensitive |
CAS DataBase Reference | 1575-61-7(CAS DataBase Reference) |
Safety information for 5-Chlorovaleryl chloride
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H314:Skin corrosion/irritation |
Precautionary Statement Codes |
P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 5-Chlorovaleryl chloride
InChIKey | SVNNWKWHLOJLOK-UHFFFAOYSA-N |
Abamectin manufacturer
Svak Life Sciences
Aether Industries Limited
Briti Scientific
Orgamine Chemicals(I) Pvt Ltd
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