5-Chloro-2-methoxyaniline
- CAS NO.：95-03-4
- Empirical Formula: C7H8ClNO
- Molecular Weight: 157.6
- MDL number: MFCD00007777
- EINECS: 202-385-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 14:15:32
What is 5-Chloro-2-methoxyaniline?
Chemical properties
Off-white to tan crystalline powder or flakes
The Uses of 5-Chloro-2-methoxyaniline
5-Chloro-2-methoxybenzenamine is used in preparation of appetite-modulating molecules.
Preparation
4-Chloro-1-methoxy-2-nitrobenzene reduction.
Purification Methods
Purify the aniline by steam distillation and recrystallisation from H2O or 40% aqueous EtOH. The N-acetate forms needles from hot H2O with m 104o, the N-benzoyl derivative forms needles from aqueous EtOH with m 77-78o, and the picrate has m 194o(dec). [Raiford & Colbert J Am Chem Soc 48 2657 1926, Beilstein 13 IV 879.]
Properties of 5-Chloro-2-methoxyaniline
| Melting point: | 81-83 °C(lit.) |
| Boiling point: | 135 °C (5.85078 mmHg) |
| Density | 1.1760 (rough estimate) |
| refractive index | 1.5430 (estimate) |
| Flash point: | 136 °C |
| storage temp. | Amber Vial, -20°C Freezer, Under inert atmosphere |
| solubility | Chloroform (Slightly), DMSO (Slightly) |
| form | Solid |
| pka | 3.48±0.10(Predicted) |
| color | Pale Grey to Light Grey |
| BRN | 879161 |
| Stability: | Light Sensitive |
| CAS DataBase Reference | 95-03-4(CAS DataBase Reference) |
| EPA Substance Registry System | Benzenamine, 5-chloro-2-methoxy- (95-03-4) |
Safety information for 5-Chloro-2-methoxyaniline
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06  Health Hazard GHS08 |
| GHS Hazard Statements |
H301:Acute toxicity,oral H311:Acute toxicity,dermal H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H373:Specific target organ toxicity, repeated exposure |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 5-Chloro-2-methoxyaniline
5-Chloro-2-methoxyaniline manufacturer
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