5-Aminolevulinic acid methyl ester hydrochloride

Synonym(s):5-Amino-4-oxopentanoic acid methyl ester;5-Aminolevulinic acid methyl ester

CAS NO.：79416-27-6
Empirical Formula: C6H12ClNO3
Molecular Weight: 181.62
MDL number: MFCD00012868
EINECS: 279-151-1
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-04 20:04:50

5-Aminolevulinic acid methyl ester hydrochloride Structural

What is 5-Aminolevulinic acid methyl ester hydrochloride?

Chemical properties

5-Aminolevulinic acid methyl ester hydrochloride is white powder

The Uses of 5-Aminolevulinic acid methyl ester hydrochloride

5-Aminolevulinic acid methyl ester hydrochloride is used in photodynamic therapy.

Definition

ChEBI: The hydrochloride salt of methyl 5-aminolevulinate. A prodrug, it is metabolised to protoporphyrin IX, a photosensitizer, and is used in the photodynamic treatment of non-melanoma skin cancer (including basal cell carcinoma). Topical application results in an accumulation of protoporphyrin IX in the skin lesions to which the cream has been applied. Subsequent illumination with red light results in the generation of toxic singlet oxygen that destroys cell membranes and thereby kills the tumour cells.

brand name

Metvixia (PhotoCure, Norway).

Biochem/physiol Actions

Methyl δ-aminolevulinate (methyl-ALA, MAL) and 5-Aminolevulinic acid (5-ALA) are commonly used in photosentizer reagents for photodynamic therapy to treat conditions such as Acne vulgaris and hypertrophic scarring.

Properties of 5-Aminolevulinic acid methyl ester hydrochloride

Melting point:	119-121°
storage temp.	2-8°C
solubility	DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form	Solid
color	White to Off-White
Water Solubility	very faint turbidity
Sensitive	Light Sensitive/Hygroscopic
Stability:	Hygroscopic
CAS DataBase Reference	79416-27-6(CAS DataBase Reference)

Safety information for 5-Aminolevulinic acid methyl ester hydrochloride

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.