5-Aminolevulinic acid methyl ester hydrochloride
Synonym(s):5-Amino-4-oxopentanoic acid methyl ester;5-Aminolevulinic acid methyl ester
- CAS NO.：79416-27-6
- Empirical Formula: C6H12ClNO3
- Molecular Weight: 181.62
- MDL number: MFCD00012868
- EINECS: 279-151-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-21 22:41:43
What is 5-Aminolevulinic acid methyl ester hydrochloride?
Chemical properties
5-Aminolevulinic acid methyl ester hydrochloride is white powder
The Uses of 5-Aminolevulinic acid methyl ester hydrochloride
5-Aminolevulinic acid methyl ester hydrochloride is used in photodynamic therapy.
Definition
ChEBI: The hydrochloride salt of methyl 5-aminolevulinate. A prodrug, it is metabolised to protoporphyrin IX, a photosensitizer, and is used in the photodynamic treatment of non-melanoma skin cancer (including basal cell carcinoma). Topical application results in an accumulation of protoporphyrin IX in the skin lesions to which the cream has been applied. Subsequent illumination with red light results in the generation of toxic singlet oxygen that destroys cell membranes and thereby kills the tumour cells.
brand name
Metvixia (PhotoCure, Norway).
Biochem/physiol Actions
Methyl δ-aminolevulinate (methyl-ALA, MAL) and 5-Aminolevulinic acid (5-ALA) are commonly used in photosentizer reagents for photodynamic therapy to treat conditions such as Acne vulgaris and hypertrophic scarring.
Properties of 5-Aminolevulinic acid methyl ester hydrochloride
| Melting point: | 119-121° |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| form | Solid |
| color | White to Off-White |
| Water Solubility | very faint turbidity |
| Sensitive | Light Sensitive/Hygroscopic |
| Stability: | Hygroscopic |
| CAS DataBase Reference | 79416-27-6(CAS DataBase Reference) |
Safety information for 5-Aminolevulinic acid methyl ester hydrochloride
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 5-Aminolevulinic acid methyl ester hydrochloride
| InChIKey | UJYSYPVQHFNBML-UHFFFAOYSA-N |
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