5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE
- CAS NO.：218457-67-1
- Empirical Formula: C15H18N2O
- Molecular Weight: 242.32
- MDL number: MFCD00052647
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-09-04 16:42:00
What is 5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE?
Description
CB-103 (218457-67-1) is an orally active inhibitor of the Notch signaling activation complex (IC50’s from 0.9 to 3.9 μM in various cell-based assays), the most downstream level of the Notch signaling pathway. It inhibited the growth of Notch-addicted human T cell acute lymphoblastic leukemia cells as well as other cell lines.? CB-103 also inhibited the growth of human breast cancer and leukemia xenografts without the intestinal toxicity associated with γ-secretase Notch inhibitors.
References
Lehal et al. (2020), Pharmacological disruption of the Notch transcription factor complex; Proc. Natl. Acad. Sci. USA, 117 16292
Properties of 5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE
| Melting point: | 89-90 |
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO (>30 mg/ml) |
| form | solid |
| color | Off-white to pale orange |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| CAS DataBase Reference | 218457-67-1(CAS DataBase Reference) |
Safety information for 5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for 5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE
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