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HomeProduct name list5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE

5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE

5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE Structural

What is 5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE?

Description

CB-103 (218457-67-1) is an orally active inhibitor of the Notch signaling activation complex (IC50’s from 0.9 to 3.9 μM in various cell-based assays), the most downstream level of the Notch signaling pathway. It inhibited the growth of Notch-addicted human T cell acute lymphoblastic leukemia cells as well as other cell lines.? CB-103 also inhibited the growth of human breast cancer and leukemia xenografts without the intestinal toxicity associated with γ-secretase Notch inhibitors.

References

Lehal et al. (2020), Pharmacological disruption of the Notch transcription factor complex; Proc. Natl. Acad. Sci. USA, 117 16292

Properties of 5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE

Melting point: 89-90
storage temp.  2-8°C
solubility  Soluble in DMSO (>30 mg/ml)
form  solid
color  Off-white to pale orange
Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
CAS DataBase Reference 218457-67-1(CAS DataBase Reference)

Safety information for 5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.

Computed Descriptors for 5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE

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