5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a]
Synonym(s):5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline;LDN-193719;VU0469381
- CAS NO.:1062368-49-3
- Empirical Formula: C22H16N4O
- Molecular Weight: 352.39
- MDL number: MFCD28099805
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-02 10:08:32
What is 5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a]?
The Uses of 5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a]
LDN 193719 is a selective bone morphogenetic protein receptor (BMP) inhibitor for ALK2.
Biological Activity
ml347 is a potent and selective inhibitor of bone morphogenetic protein (bmp) receptor with ic50 value of 32nm against alk2 [1].ml347 is discovered as a selective inhibitor of bmp type-i receptor alk2 versus alk3 and is identified as a probe molecule. in the in vitro kinase assay, ml347 shows potent inhibitory activities against alk1 and alk2 with ic50 values of 46 and 32 nm, respectively. the ic50 value of it for alk3 is more than 10μm, demonstrating that ml347 is 300-fold more potent against alk2. besides that, ml347 exerts no inhibition effect on other related kinases such as alk6 and kdr. moreover, ml347 also shows effective inhibition with ic50 value of 152nm in the bmp4 cell based assay using c2c12bra cells [1].
storage
Store at +4°C
References
[1] engers d w, frist a y, lindsley c w, et al. synthesis and structure–activity relationships of a novel and selective bone morphogenetic protein receptor (bmp) inhibitor derived from the pyrazolo [1.5-a] pyrimidine scaffold of dorsomorphin: the discovery of ml347 as an alk2 versus alk3 selective mlpcn probe. bioorganic & medicinal chemistry letters, 2013, 23(11): 3248-3252.
Properties of 5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a]
Melting point: | 209-210℃ |
storage temp. | Store at -20°C |
solubility | insoluble in H2O; insoluble in EtOH; ≥5.87 mg/mL in DMSO with gentle warming |
form | solid |
color | Light yellow to yellow |
Safety information for 5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a]
Signal word | Danger |
Pictogram(s) |
Exclamation Mark Irritant GHS07 Health Hazard GHS08 Environment GHS09 |
GHS Hazard Statements |
H302:Acute toxicity,oral H372:Specific target organ toxicity, repeated exposure H410:Hazardous to the aquatic environment, long-term hazard |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P273:Avoid release to the environment. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
Computed Descriptors for 5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a]
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