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HomeProduct name list5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole

5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole

5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole Structural

What is 5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole?

Chemical properties

Off-white Solid

The Uses of 5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole

An intermediate in the preparation of labelled Candesartan.

The Uses of 5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole

5-?(4''-?Methyl-?[1,?1''-?biphenyl]?-?2-?yl)?-?1-?trityl-?1H-?tetrazole is a reactant in the synthesis of anti-microbial agents.

Synthesis

5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole is prepared by the reaction of trityl chloride and 2-(tetrazol-5-yl)-4'-methyl-1,1'-biphenyl. The specific synthesis steps are as follows:
Dissolve compound 2 (200 g) with stirring at 40°C 700mL of acetone, Aqueous sodium hydroxide solution (40.67 g sodium hydroxide dissolved in 160 mL water) is added, Continue stirring for 1h, A solution of triphenylchloromethane in acetone (270.8 g of triphenylmethyl chloride dissolved in 800 mL of acetone) was initially added dropwise. The solid was added dropwise and gradually evolved into a white turbid liquid. The reaction was monitored by TLC until it was completely filtered off and washed with water to give a solid as intermediate 3. The solid was blow dried at 50°C to give white intermediate 3 (385 g), yield: 95.2%, HPLC: 99.44%.
5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole synthesis

Properties of 5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole

Melting point: 166-169 °C(Solv: ethyl acetate (141-78-6); dichloromethane (75-09-2))
Boiling point: 681.6±65.0 °C(Predicted)
Density  1.13±0.1 g/cm3(Predicted)
storage temp.  Inert atmosphere,Room Temperature
solubility  Chloroform (Slightly)
form  Solid
pka 0.30±0.10(Predicted)
color  Off-White
CAS DataBase Reference 124750-53-4(CAS DataBase Reference)

Safety information for 5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole

Signal word Danger
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P312:Call a POISON CENTER or doctor/physician if you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P403+P233:Store in a well-ventilated place. Keep container tightly closed.

Computed Descriptors for 5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole

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