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HomeProduct name list4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE

4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE

4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE Structural

What is 4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE?

The Uses of 4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE

4alpha-Phorbol 12-myristate 13-acetate is a non-tumor promoting phorbol ester derivative that has been used as a negative control for PMA, a tumor promoter and activator of PKC. However, 4α-PMA has also been shown to be a reasonably potent activator of TRPV4 channels, making it a useful tool for structure-activity investigations via comparison to the very similar compound, 4α-PDD, which demonstrates 50 times more affinity for TRPV4. Furthermore, this compound has also been shown to increase PGHS-2 mRNA significantly in murine keratinocytes.

What are the applications of Application

4α-Phorbol 12-myristate 13-acetate is a phorbol ester analog, binds to TRPV4, increases PGHS-2 mRNA in murine keratinocytes

Biochem/physiol Actions

Negative control for phorbol ester activation of protein kinase C.

Properties of 4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE

storage temp.  -20°C
solubility  H2O: ~2 μM Though having aqueous solubility, it is recommended that this compound first be dissolved in a water miscible organic solvent before dilution to working concentrations in aqueous media.
form  solid
color  white
Sensitive  Light Sensitive

Safety information for 4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE

Computed Descriptors for 4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE

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