4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE
- CAS NO.：63597-44-4
- Empirical Formula: C36H56O8
- Molecular Weight: 616.83
- MDL number: MFCD00153860
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 09:03:08
What is 4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE?
The Uses of 4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE
4alpha-Phorbol 12-myristate 13-acetate is a non-tumor promoting phorbol ester derivative that has been used as a negative control for PMA, a tumor promoter and activator of PKC. However, 4α-PMA has also been shown to be a reasonably potent activator of TRPV4 channels, making it a useful tool for structure-activity investigations via comparison to the very similar compound, 4α-PDD, which demonstrates 50 times more affinity for TRPV4. Furthermore, this compound has also been shown to increase PGHS-2 mRNA significantly in murine keratinocytes.
What are the applications of Application
4α-Phorbol 12-myristate 13-acetate is a phorbol ester analog, binds to TRPV4, increases PGHS-2 mRNA in murine keratinocytes
Biochem/physiol Actions
Negative control for phorbol ester activation of protein kinase C.
Properties of 4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE
| storage temp. | -20°C |
| solubility | H2O: ~2 μM Though having aqueous solubility, it is recommended that this compound first be dissolved in a water miscible organic solvent before dilution to working concentrations in aqueous media. |
| form | solid |
| color | white |
| Sensitive | Light Sensitive |
Safety information for 4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE
Computed Descriptors for 4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE
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