S-Methyl methanethiolsulfonate
Synonym(s):S-Methyl thiomethanesulfonate;MMTS
- CAS NO.:2949-92-0
- Empirical Formula: C2H6O2S2
- Molecular Weight: 126.2
- MDL number: MFCD00007565
- EINECS: 220-970-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-06 19:41:26
What is S-Methyl methanethiolsulfonate?
Chemical properties
Light Yellow Liquid
The Uses of S-Methyl methanethiolsulfonate
S-Methyl methanethiolsulfonate is used for the rapid and selective modification of sulfhydryl groups of enzymes and it is also useful for mapping the pore-lining regions of the ryanodine receptor.
The Uses of S-Methyl methanethiolsulfonate
carbonyl reactive homobifunctional cross-linking reagent cleavable with periodate
The Uses of S-Methyl methanethiolsulfonate
S-Methyl methanethiosulfonate was used as sulfenylating agent for β-keto sulfoxides, methylene compounds, half-esters of malonic acids and aryl Grignard reagents. It was also used as a reagent to trap the natural thiol-disulfide state of the proteins.
What are the applications of Application
Methyl Methanethiosulfonate is a reagent for the modification of sulfhydryl groups of enzymes
Definition
ChEBI: A sulfonic acid derivative obtained by condensaton of methanesulfonic acid with methanethiol.
Synthesis Reference(s)
The Journal of Organic Chemistry, 49, p. 2281, 1984 DOI: 10.1021/jo00186a039
Synthetic Communications, 20, p. 365, 1990 DOI: 10.1080/00397919008052777
General Description
Interaction of S-methyl methanethiosulfonate (MMTS) with dipalmitoylphosphatidylcholine (DPPC) bilayers has been investigated by FTIR and surface-enhanced Raman spectroscopy.
Purification Methods
Purify it by fractional distillation under reduced pressure, IR: 1350, 750 cm-1 . [Applegate et al. J Org Chem 38 943 1973, Beilstein 4 IV 31.]
Properties of S-Methyl methanethiolsulfonate
Melting point: | 117.0-119.0 °C |
Boiling point: | 69-71 °C0.4 mm Hg(lit.) |
Density | 1.337 g/mL at 25 °C(lit.) |
refractive index | n |
Flash point: | 190 °F |
storage temp. | 2-8°C |
solubility | chloroform: soluble750mg + 5 ml Chloroformmg/mL, colorless to light greenish-yellow |
form | clear liquid |
color | Colorless to Red to Green |
Odor | at 0.10 % in propylene glycol. sulfurous pungent roasted |
BRN | 1446059 |
Stability: | Water Sensitive |
CAS DataBase Reference | 2949-92-0(CAS DataBase Reference) |
NIST Chemistry Reference | S-methyl methanethiosulphonate(2949-92-0) |
EPA Substance Registry System | Methanesulfonothioic acid, S-methyl ester (2949-92-0) |
Safety information for S-Methyl methanethiolsulfonate
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H227:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P501:Dispose of contents/container to..… |
Computed Descriptors for S-Methyl methanethiolsulfonate
InChIKey | XYONNSVDNIRXKZ-UHFFFAOYSA-N |
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