4-Formyl-2-isopropylthiazole

CAS NO.：133047-46-8
Empirical Formula: C7H9NOS
Molecular Weight: 155.22
MDL number: MFCD06660125
EINECS: 604-604-1
SAFETY DATA SHEET (SDS)
Update Date: 2023-11-01 09:12:58

What is 4-Formyl-2-isopropylthiazole?

Synthesis

A solution of 3.1 g (15.6 mmol) of ethyl 2-isopropylthiazole-4-carboxylate in 50 ml of dichloromethane was cooled under N2 atmosphere to -78° C and treated dropwise with 15.6 ml (23.4 mmol) of a 1.5 M solution of diisobutylaluminum hydride in toluene over 1.5 h. After being stirred for an additional 0.5 h, the solution was quenched with 5 ml of methanol followed by 15 ml of aqueous Rochelle's salt. The resulting mixture was partitioned between chloroform and aqueous Rochelle's salt, dried over Na2SO4, and concentrated to provide 1.37 g (56 %) of the crude 4-Formyl-2-isopropylthiazole.

Properties of 4-Formyl-2-isopropylthiazole

Boiling point:	232.4±13.0 °C(Predicted)
Density	1.159±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	1.10±0.10(Predicted)
InChI	InChI=1S/C7H9NOS/c1-5(2)7-8-6(3-9)4-10-7/h3-5H,1-2H3

Safety information for 4-Formyl-2-isopropylthiazole

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.