4-Methylpyridin-2-amine
Synonym(s):2-Amino-4-picoline
- CAS NO.:695-34-1
- Empirical Formula: C6H8N2
- Molecular Weight: 108.14
- MDL number: MFCD00149166
- EINECS: 211-780-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-20 17:10:30
What is 4-Methylpyridin-2-amine?
Chemical properties
Light yellow to brown flakes
The Uses of 4-Methylpyridin-2-amine
Intermediate, medicine.
The Uses of 4-Methylpyridin-2-amine
2-Amino-4-methylpyridine has been used in the synthesis of 2-amino-4-methyl-pyridinium 2-hy-droxy-benzoate. It is potent inhibitor of NOS2 (iNOS) in vitro. It is used as pharmaceutical intermediate.
What are the applications of Application
2-Amino-4-methylpyridine is a potent inhibitor of NOS2 (iNOS)
Synthesis Reference(s)
The Journal of Organic Chemistry, 72, p. 4554, 2007 DOI: 10.1021/jo070189y
General Description
2-Amino-4-methylpyridine acts as ligand and forms methoxo-bridged copper(II) complexes.
Biochem/physiol Actions
2-Amino-4-methylpyridine inhibits the activity of inducible NO synthase isolated from mouse RAW 264.7 cells in vitro.
Synthesis
A mixture of 2-amino-3-chloro-4-methylpyridine 0.96 g (0. 0067πο1) and benzoic acid, 1.83 g (0.015 mol) was added, the copper powder was added, reacted at 150 ° C for 1 h, and the reaction solution was added to water, Adding the decolorizer, adjusting the pH of the filtered solution to pH 9, filtering and drying the filter cake to obtain 0.65 g of crude 4-Methylpyridin-2-amine as a yellow solid, the yield was 89.3percent. The crude 0.65g dissolved in dilute hydrochloric acid solution to the crude product completely dissolved to obtain a salt solution, adding ethyl acetate to the salt solution to extract the water phase, slowly adding sodium bicarbonate to the aqueous phase Solution to pH 9, the solid was completely precipitated, filtered, and the filtrate was washed with distilled water and dried in vacuo to give 0.53 g of 4-Methylpyridin-2-amine as a pale yellow solid.
Purification Methods
Crystallise it from EtOH or a 2:1 *benzene/acetone mixture, and dry it under vacuum as in the prevous entry. [Beilstein 22/9 V 325.]
Properties of 4-Methylpyridin-2-amine
Melting point: | 96-99 °C (lit.) |
Boiling point: | 230 °C (lit.) |
Density | 1.0275 (estimate) |
vapor pressure | 3.71Pa at 25℃ |
refractive index | 1.5560 (estimate) |
Flash point: | 118 °C |
storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
solubility | DMF: freely soluble |
pka | pK1: 7.48(+1) (25°C) |
form | Flakes |
color | Slightly yellow to beige or brown |
Water Solubility | SOLUBLE |
Sensitive | Hygroscopic |
Merck | 14,466 |
BRN | 107066 |
CAS DataBase Reference | 695-34-1(CAS DataBase Reference) |
NIST Chemistry Reference | 2-Pyridinamine, 4-methyl-(695-34-1) |
EPA Substance Registry System | 2-Pyridinamine, 4-methyl- (695-34-1) |
Safety information for 4-Methylpyridin-2-amine
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08 |
GHS Hazard Statements |
H373:Specific target organ toxicity, repeated exposure |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P314:Get medical advice/attention if you feel unwell. |
Computed Descriptors for 4-Methylpyridin-2-amine
Abamectin manufacturer
ALTRAKEM PHARMA LIFE SCIENCES PRIVATE LIMITED
Sintilla Medcoms Pvt Ltd
Nasense Labs Private Limited
Rivashaa Agrotech Biopharma Pvt. Ltd.
Allmpus Laboratories Pvt Ltd
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