4-Methylpyridazine

CAS NO.：1120-88-3
Empirical Formula: C5H6N2
Molecular Weight: 94.11
MDL number: MFCD00011594
SAFETY DATA SHEET (SDS)
Update Date: 2024-01-02 16:51:54

What is 4-Methylpyridazine?

Chemical properties

Clear yellow liquid

The Uses of 4-Methylpyridazine

4-Methylpyridazine was used in the preparation of series of novel pyridazine derivatives structurally related to bipyridine cardiotonics.

Reactions

4-methylpyridazine could be used as a starting material to synthesize a series of novel pyridazine derivatives structurally related to bipyridine cardiotonics[1].
Pyridazine (pydz) and 4-methylpyridazine (4Me-pydz) could form stable bis(monodentate) complexes of general formulae fac-[PtXMe3L2](X = Cl, Br or I) and fac-[ReX(CO)3L2](X = Cl, Br or I). These complexes in above-ambient temperature solutions exhibit 1,2-fluxional shifts between the nitrogen donor pairs of each ring[2].

General Description

Products of reaction of methyl iodide with 4-methylpyridazine has been investigated by NMR spectra. Solvent free oxidation of 4-methylpyridazine by acetyl peroxyborate, peracetic acid and hydrogen peroxide has been reported.

References

[1] Haider N, et al. Pyridazine analogues of biologically active compounds. Part 5: Novel potential cardiotonics of the amrinone type. Organic Electronics, 1989.
[2] Abel E, et al. 1,2-Metallotropic shifts in trimethylplatinum(IV) and tricarbonylrhenium(I) halide complexes of pyridazine and 4-methylpyridazine. Journal of the Chemical Society, Dalton Transactions, 1994; 445-455.

Properties of 4-Methylpyridazine

Boiling point:	98-100 °C/11 mmHg (lit.)
Density	1.06 g/mL at 25 °C (lit.)
refractive index	n20/D 1.521(lit.)
Flash point:	222 °F
storage temp.	Sealed in dry,Room Temperature
form	Liquid
pka	3.74±0.10(Predicted)
Specific Gravity	1.060
color	Clear yellow
λmax	292nm(H2O)(lit.)
BRN	105689
InChI	InChI=1S/C5H6N2/c1-5-2-3-6-7-4-5/h2-4H,1H3
CAS DataBase Reference	1120-88-3(CAS DataBase Reference)

Safety information for 4-Methylpyridazine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.