4-Methylphenylacetic acid
Synonym(s):4-Methylphenylacetic acid
- CAS NO.：622-47-9
- Empirical Formula: C9H10O2
- Molecular Weight: 150.17
- MDL number: MFCD00004353
- EINECS: 210-738-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-09 16:05:57
What is 4-Methylphenylacetic acid?
Chemical properties
white fine crystalline powder
The Uses of 4-Methylphenylacetic acid
p-Tolylacetic acid is a reagent used in the preparation of quaternary amines and epithelial sodium channel inhibition in bronchial epithelium.
Synthesis Reference(s)
The Journal of Organic Chemistry, 48, p. 1919, 1983 DOI: 10.1021/jo00159a031
Tetrahedron Letters, 28, p. 2633, 1987 DOI: 10.1016/S0040-4039(00)96167-7
Purification Methods
Crystallise the acid from heptane or water. [Beilstein 9 IV 1795.]
Properties of 4-Methylphenylacetic acid
| Melting point: | 88-92 °C (lit.) |
| Boiling point: | 265-267 °C (lit.) |
| Density | 1.0858 (rough estimate) |
| refractive index | 1.5002 (estimate) |
| Flash point: | 265-267°C |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| pka | pK1:4.370 (25°C) |
| form | Fine Crystalline Powder |
| color | White |
| BRN | 2043528 |
| InChI | InChI=1S/C9H10O2/c1-7-2-4-8(5-3-7)6-9(10)11/h2-5H,6H2,1H3,(H,10,11) |
| CAS DataBase Reference | 622-47-9(CAS DataBase Reference) |
| NIST Chemistry Reference | p-Tolylacetic acid(622-47-9) |
Safety information for 4-Methylphenylacetic acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 4-Methylphenylacetic acid
| InChIKey | GXXXUZIRGXYDFP-UHFFFAOYSA-N |
| SMILES | C1(CC(O)=O)=CC=C(C)C=C1 |
4-Methylphenylacetic acid manufacturer
BTC pharm India
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JSK Chemicals
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product: p-Tolylacetic acid, 98% 622-47-9 99%
Syn Finechem Laboratories Pvt Ltd.
1Y
Phone:+91-9848230784
Whatsapp: +91 9848230784
product: 622-47-9 p-Tolylacetic acid 98%
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