4-Methylphenylacetic acid

Synonym(s):4-Methylphenylacetic acid

white fine crystalline powder

p-Tolylacetic acid is a reagent used in the preparation of quaternary amines and epithelial sodium channel inhibition in bronchial epithelium.

The Journal of Organic Chemistry, 48, p. 1919, 1983 DOI: 10.1021/jo00159a031
Tetrahedron Letters, 28, p. 2633, 1987 DOI: 10.1016/S0040-4039(00)96167-7

Crystallise the acid from heptane or water. [Beilstein 9 IV 1795.]

Melting point:	88-92 °C (lit.)
Boiling point:	265-267 °C (lit.)
Density	1.0858 (rough estimate)
refractive index	1.5002 (estimate)
Flash point:	265-267°C
storage temp.	Sealed in dry,Room Temperature
solubility	soluble in Methanol
pka	pK1:4.370 (25°C)
form	Fine Crystalline Powder
color	White
BRN	2043528
InChI	InChI=1S/C9H10O2/c1-7-2-4-8(5-3-7)6-9(10)11/h2-5H,6H2,1H3,(H,10,11)
CAS DataBase Reference	622-47-9(CAS DataBase Reference)
NIST Chemistry Reference	p-Tolylacetic acid(622-47-9)

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.