4-Methoxyphenyl isocyanate

What is 4-Methoxyphenyl isocyanate?

clear colorless liquid

4-Methoxyphenyl isocyanate has been used in the preparation of:

6H-indolo[2,3-b]quinolines
1-[2-(2-furyl)-8-methyl-9-substituted-8H-pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c] pyrimidin-5-yl]-3-(4-methoxyphenyl)urea

Tetrahedron Letters, 17, p. 2691, 1976 DOI: 10.1016/S0040-4039(00)77797-5

Cyclotrimerization of 4-methoxyphenyl isocyanate by CO₂-protected N-heterocyclic carbenes based on tetrahydropyrimidin-2-ylidenes has been reported.

Melting point:	101 °C
Boiling point:	106-110 °C16 mm Hg(lit.)
Density	1.151 g/mL at 25 °C(lit.)
refractive index	n20/D 1.548(lit.)
Flash point:	209 °F
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	soluble in Chloroform, Methanol
form	Liquid
Specific Gravity	1.151
color	Clear colorless
Sensitive	Moisture Sensitive
BRN	471920
CAS DataBase Reference	5416-93-3(CAS DataBase Reference)
NIST Chemistry Reference	P-methoxy phenyl isocyanate(5416-93-3)
EPA Substance Registry System	Benzene, 1-isocyanato-4-methoxy- (5416-93-3)

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 Health Hazard GHS08
GHS Hazard Statements	H314:Skin corrosion/irritation H317:Sensitisation, Skin H334:Sensitisation, respiratory
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.