3-Methoxybenzaldehyde

Synonym(s):3-Methoxybenzaldehyde;m-Anisaldehyde

CAS NO.：591-31-1
Empirical Formula: C8H8O2
Molecular Weight: 136.15
MDL number: MFCD00003361
EINECS: 209-712-8
SAFETY DATA SHEET (SDS)
Update Date: 2025-01-27 09:38:02

What is 3-Methoxybenzaldehyde?

Chemical properties

clear pale yellow to yellow liquid

The Uses of 3-Methoxybenzaldehyde

3-Methoxybenzaldehyde is used to prepare 3-(3-methoxy-phenyl)-1-phenyl-propenone by reaction with benzldehyde. It is used as an eluent for mono-13C isotopomers of vanillin in normal phase silica gel chromatography. It acts as an inhibitor of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism.

Definition

ChEBI: 3-methoxybenzaldehyde is a member of the class of benzaldehydes in which the hydrogen at position 3 of benzaldehyde has been replaced by a methoxy group. It has a role as a Brassica napus metabolite. It is a member of benzaldehydes and a monomethoxybenzene.

Synthesis Reference(s)

Synthetic Communications, 24, p. 2011, 1994 DOI: 10.1080/00397919408010209

General Description

m-Anisaldehyde has significant antifungal activity against Candida sp., including the azole-resistant strains.

Safety Profile

Mutation data reported. Whenheated to decomposition it emits acrid smoke andirritating vapors.

Purification Methods

Wash it with saturated aqueous NaHCO3, then H2O, dry it with anhydrous MgSO4 and distil it under reduced pressure under N2. Store it under N2 in sealed glass ampoules. [Beilstein 8 IV 241.]

Properties of 3-Methoxybenzaldehyde

Melting point:	187 °C
Boiling point:	143 °C50 mm Hg(lit.)
Density	1.117 g/mL at 20 °C(lit.)
vapor pressure	1.3 hPa (73 °C)
refractive index	n20/D 1.553(lit.)
Flash point:	>230 °F
storage temp.	Store below +30°C.
solubility	Chloroform, Methanol (Slightly)
form	Liquid
Specific Gravity	1.118
color	Clear pale yellow to yellow
Odor	at 100.00?%. anisic
Water Solubility	insoluble
Sensitive	Air Sensitive
BRN	606013
CAS DataBase Reference	591-31-1(CAS DataBase Reference)
NIST Chemistry Reference	Benzaldehyde, 3-methoxy-(591-31-1)
EPA Substance Registry System	Benzaldehyde, 3-methoxy- (591-31-1)

Safety information for 3-Methoxybenzaldehyde

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.