4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97%

Synonym(s):4-Methoxy-N-(2,4,6-trimethylphenyl)-benzenesulfonamide;N-Mesityl-4-methoxybenzenesulfonamide

CAS NO.：349085-82-1
Empirical Formula: C16H19NO3S
Molecular Weight: 305.39
MDL number: MFCD02007969
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 20:33:22

4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97% Structural

What is 4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97%?

Description

GSK-137647 (349085-82-1) is a potent and selective agonist at free fatty acid receptor 4 (FFA4), also known as GPR120. pEC50s= 6.3, 6.2 and 6.1 for human, mouse and rat receptor respectively.1 GSK-137647 enhances glucose-stimulated insulin secretion in mouse insulinoma cells and induces intracellular calcium increase in U2OS osteosarcoma cells expressing GPR120.2

The Uses of 4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97%

4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide is involved in long-chain fatty acid stimulated GLP-1 secretion and has been implicated in glucose homeostasis, adiposity, and regulation of the anti-inflammatory response. It enhances glucose-stimulated insulin secretion in MIN6 cells. It induces intracellular calcium accumulation in U2OS cells; this activity is inhibited by AH 7614.

in vitro

gsk137647a (50 μm) induced a concentration-dependent increase in glucose (25 mm)-stimulated insulin secretion in min6 mouse insulinoma cell line [1]. in addition, gsk137647a (100 μm) induced a modest increase in glp-1 secretion in the human intestinal cell line nci-h716. moreover, gsk137647a induced intracellular calcium accumulation in u2os cells [1].

in vivo

gsk137647a (50 μm) induced active glp-1 release by mouse circumvallate papillae (cvps) [2].

storage

Store at RT

References

1) Martin?et al. (2012),?Lipid-mediated release of GLP-1 by mouse taste buds from circumvallate papillae: putative involvement of GPR120 and impact on taste sensitivity; J. Lipid Res.,?53?2256 2) Sparks?et al. (2014),?Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120); Bioorg. Med. Chem. Lett.,?24?3100

Properties of 4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97%

Boiling point:	438.1±55.0 °C(Predicted)
Density	1.214±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Soluble to 100 mM in DMSO and to 50 mM in ethanol.
form	powder
pka	9.23±0.10(Predicted)
color	white to beige
Stability:	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
CAS DataBase Reference	349085-82-1

Safety information for 4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97%

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.