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HomeProduct name list4-Hydroxytolbutamide

4-Hydroxytolbutamide

Synonym(s):N-(Butylaminocarbonyl)-4-hydroxymethylbenzenesulfonamide

  • CAS NO.:5719-85-7
  • Empirical Formula: C12H18N2O4S
  • Molecular Weight: 286.35
  • MDL number: MFCD00144466
  • EINECS: 200-835-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-28 23:16:16
4-Hydroxytolbutamide Structural

What is 4-Hydroxytolbutamide?

Description

4-hydroxy Tolbutamide is a cytochrome P450 2C8 (CYP2C8) and CYP2C9 metabolite of tolbutamide, a first-generation potassium channel blocker. Tolbutamide 4-hydroxylation is an often used probe reaction in the pharmaceutical industry for the characterization of CYP2C8 and CYP2C9 involvement in the metabolism of clinical drugs.

Chemical properties

White Solid

The Uses of 4-Hydroxytolbutamide

4-Hydroxytolbutamide has been used as a standard to assay the fungal biotransformation of tolbutamide to 4′-hydroxytolbutamide.

The Uses of 4-Hydroxytolbutamide

A metabolite of Tolbutamide. Formed by the cytochrome CYP2CIIC8 and IIC9 subfamily of P450 enzymes

What are the applications of Application

Hydroxy Tolbutamide is a P450 2C8 (CYP2C8) and CYP2C9 metabolite of tolbutamide, a first-generation potassium channel blocker.

Definition

ChEBI: A urea that consists of 1-butylurea having a 4-hydroxymethylbenzenesulfonyl group attached at the 3-position.

Properties of 4-Hydroxytolbutamide

Melting point: 100-102 °C
Density  1.268±0.06 g/cm3(Predicted)
Flash point: 2℃
storage temp.  2-8°C
solubility  ethanol: 12 mg/mL
form  Solid
pka 4.96±0.10(Predicted)
color  white

Safety information for 4-Hydroxytolbutamide

Signal word Danger
Pictogram(s)
ghs
Flame
Flammables
GHS02
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H225:Flammable liquids
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P337+P313:IF eye irritation persists: Get medical advice/attention.
P403+P235:Store in a well-ventilated place. Keep cool.

Computed Descriptors for 4-Hydroxytolbutamide

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