4-Hydroxytolbutamide
Synonym(s):N-(Butylaminocarbonyl)-4-hydroxymethylbenzenesulfonamide
- CAS NO.:5719-85-7
- Empirical Formula: C12H18N2O4S
- Molecular Weight: 286.35
- MDL number: MFCD00144466
- EINECS: 200-835-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 23:16:16
What is 4-Hydroxytolbutamide?
Description
4-hydroxy Tolbutamide is a cytochrome P450 2C8 (CYP2C8) and CYP2C9 metabolite of tolbutamide, a first-generation potassium channel blocker. Tolbutamide 4-hydroxylation is an often used probe reaction in the pharmaceutical industry for the characterization of CYP2C8 and CYP2C9 involvement in the metabolism of clinical drugs.
Chemical properties
White Solid
The Uses of 4-Hydroxytolbutamide
4-Hydroxytolbutamide has been used as a standard to assay the fungal biotransformation of tolbutamide to 4′-hydroxytolbutamide.
The Uses of 4-Hydroxytolbutamide
A metabolite of Tolbutamide. Formed by the cytochrome CYP2CIIC8 and IIC9 subfamily of P450 enzymes
What are the applications of Application
Hydroxy Tolbutamide is a P450 2C8 (CYP2C8) and CYP2C9 metabolite of tolbutamide, a first-generation potassium channel blocker.
Definition
ChEBI: A urea that consists of 1-butylurea having a 4-hydroxymethylbenzenesulfonyl group attached at the 3-position.
Properties of 4-Hydroxytolbutamide
Melting point: | 100-102 °C |
Density | 1.268±0.06 g/cm3(Predicted) |
Flash point: | 2℃ |
storage temp. | 2-8°C |
solubility | ethanol: 12 mg/mL |
form | Solid |
pka | 4.96±0.10(Predicted) |
color | white |
Safety information for 4-Hydroxytolbutamide
Signal word | Danger |
Pictogram(s) |
Flame Flammables GHS02 Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H225:Flammable liquids H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P337+P313:IF eye irritation persists: Get medical advice/attention. P403+P235:Store in a well-ventilated place. Keep cool. |
Computed Descriptors for 4-Hydroxytolbutamide
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