4-Hydroxyphenylpyruvic acid

Synonym(s):3-(4-Hydroxyphenyl)-2-oxopropanoic acid

CAS NO.：156-39-8
Empirical Formula: C9H8O4
Molecular Weight: 180.16
MDL number: MFCD00002591
EINECS: 205-852-9
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 20:33:22

What is 4-Hydroxyphenylpyruvic acid?

Chemical properties

grey to orange-brown powder

The Uses of 4-Hydroxyphenylpyruvic acid

4-Hydroxyphenylpyruvic Acid is general organic reagent used in the synthesis of latifolicinin A analogs as inhibitors of breast cancer. Also used in the preparation of amperometric biosensors for β-triketone herbicides based on hydroxyphenylpyruvate.

What are the applications of Application

4-Hydroxyphenylpyruvic acid is an enzyme inhibitor

Definition

ChEBI: An oxo carboxylic acid that is pyruvic acid in which one of the methyl hydrogens is substituted by a 4-hydroxyphenyl group.

General Description

4-hydroxyphenylpyruvic acid can be determined in pork meat and Iberian ham samples by a sensitive method of multiple reaction monitoring (MRM) by mass spectrometry.

Purification Methods

p-Hydroxyphenylpyruvic acid [156-39-8] M 180.2, m 220o(dec), pKEst ~2.3. Crystallise it three times from 0.1M HCl/EtOH (4:1, v/v) immediately before use [Rose & Powell Biochem J 87 541 1963], or from Et2O. The 3,4-dinitrophenylhydrazone has m 178o. [Beilstein 10 IV 3630.]

Properties of 4-Hydroxyphenylpyruvic acid

Melting point:	219-220 °C (dec.) (lit.)
Boiling point:	272.96°C (rough estimate)
Density	1.2933 (rough estimate)
refractive index	1.4500 (estimate)
storage temp.	Inert atmosphere,Room Temperature
solubility	ethanol: soluble50mg/mL
form	crystalline
pka	2.50±0.54(Predicted)
color	off-white to tan
Water Solubility	slightly soluble
BRN	2691632
Stability:	Hygroscopic
CAS DataBase Reference	156-39-8(CAS DataBase Reference)
NIST Chemistry Reference	Benzenepropanoic acid, 4-hydroxy-«alpha»-oxo-(156-39-8)

Safety information for 4-Hydroxyphenylpyruvic acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention.