4-(Hydroxymethyl)benzoic acid
Synonym(s):4-(Hydroxymethyl)benzoic acid
- CAS NO.：3006-96-0
- Empirical Formula: C8H8O3
- Molecular Weight: 152.15
- MDL number: MFCD00017598
- EINECS: 628-233-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-04 20:40:58
What is 4-(Hydroxymethyl)benzoic acid?
Chemical properties
Off-white solid
The Uses of 4-(Hydroxymethyl)benzoic acid
4-(Hydroxymethyl)benzoic Acid is an intermediate in the synthesis of Eprosartan (E590100), a prototype of the imidazoleacrylic acid angiotensin II receptor antagonists used as an antihypertensive age nt.
The Uses of 4-(Hydroxymethyl)benzoic acid
This linkage reagent for SPPS is essentially acid stable. It is useful in combination with Fmoc-amino acids. Its peptide esters are usually cleaved by basic or nucleophilic reagents, especially by ammonia in the preparation of peptide amides.
The Uses of 4-(Hydroxymethyl)benzoic acid
4-(Hydroxymethyl)benzoic Acid (Eprosartan USP Related Compound E) is an intermediate in the synthesis of Eprosartan (E590100), a prototype of the imidazoleacrylic acid angiotensin II receptor antagonists used as an antihypertensive agent.
Synthesis Reference(s)
Journal of the American Chemical Society, 107, p. 1365, 1985 DOI: 10.1021/ja00291a042
Properties of 4-(Hydroxymethyl)benzoic acid
| Melting point: | 182-185 °C (lit.) |
| Boiling point: | 140-150 °C(Press: 9 Torr) |
| Density | 1.314±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO, Methanol |
| form | Coarse Fibers |
| pka | 4.16±0.10(Predicted) |
| color | White |
| BRN | 2690023 |
| CAS DataBase Reference | 3006-96-0(CAS DataBase Reference) |
Safety information for 4-(Hydroxymethyl)benzoic acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-(Hydroxymethyl)benzoic acid
| InChIKey | WWYFPDXEIFBNKE-UHFFFAOYSA-N |
4-(Hydroxymethyl)benzoic acid manufacturer
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product: 4-(Hydroxymethyl)benzoic acid
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