4'-Hydroxy-3'-methoxypropiophenone
- CAS NO.:1835-14-9
- Empirical Formula: C10H12O3
- Molecular Weight: 180.2
- MDL number: MFCD00482070
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-25 18:01:05
What is 4'-Hydroxy-3'-methoxypropiophenone?
The Uses of 4'-Hydroxy-3'-methoxypropiophenone
1-(4-Hydroxy-3-methoxyphenyl)-1-propanone is a derivative of Guaiacol, a precursor to various flavorants, such as eugenol and vanillin.
Preparation
Preparation by Fries rearrangement of 2-methoxyphenyl propionate, (b.p.20 140–143°)
with aluminium chloride in nitrobenzene, first at 60–80° for 1 h, then at r.t. overnight, at 60° for 1 h or at 50° for 5 h (44%) ;
with aluminium chloride (2 mol) in nitromethane at r.t. for 24 h (65%)
with aluminium chloride in carbon disulfide
with titanium tetrachloride (2 mol) in nitromethane at r.t. for 24 h (62%)
with stannic chloride (2 mol) in nitromethane at r.t. for 24 h (69%)
with antimony pentachloride (2 mol) in nitromethane at r.t. for 24 h (28%) with formation of important tars.
Synthesis Reference(s)
The Journal of Organic Chemistry, 15, p. 227, 1950 DOI: 10.1021/jo01148a001
Properties of 4'-Hydroxy-3'-methoxypropiophenone
Melting point: | 61-62 °C |
Boiling point: | 180-185 °C(Press: 15 Torr) |
Density | 1.126±0.06 g/cm3(Predicted) |
storage temp. | Sealed in dry,Room Temperature |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | Solid |
pka | 8.92±0.31(Predicted) |
color | White to Dark Beige |
CAS DataBase Reference | 1835-14-9(CAS DataBase Reference) |
NIST Chemistry Reference | 1-(4-hydroxy-3-methoxyphenyl)propanone(1835-14-9) |
EPA Substance Registry System | 1-Propanone, 1-(4-hydroxy-3-methoxyphenyl)- (1835-14-9) |
Safety information for 4'-Hydroxy-3'-methoxypropiophenone
Computed Descriptors for 4'-Hydroxy-3'-methoxypropiophenone
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