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HomeProduct name list4'-HYDROXY-2'-METHYLACETOPHENONE

4'-HYDROXY-2'-METHYLACETOPHENONE

  • CAS NO.:875-59-2
  • Empirical Formula: C9H10O2
  • Molecular Weight: 150.17
  • MDL number: MFCD00002303
  • EINECS: 212-874-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-05-25 18:00:59
4'-HYDROXY-2'-METHYLACETOPHENONE Structural

What is 4'-HYDROXY-2'-METHYLACETOPHENONE?

Chemical properties

off-white to beige crystalline powder

The Uses of 4'-HYDROXY-2'-METHYLACETOPHENONE

4''-Hydroxy-2''-methylacetophenone has been used in the preparation of morpholine ketone analogs as potent histamine H3 receptor inverse agonists with wake activity.

Definition

ChEBI: A member of the class of acetophenones that is acetophenone substituted by a hydroxy group at position 4 and a methyl group at position 2 respectively.

Preparation

Preparation by dealkylation of 4-hydroxy-2-methyl-5-iso-propylacetophenone with aluminium chloride in chlorobenzene at 50° (80%).

Properties of 4'-HYDROXY-2'-METHYLACETOPHENONE

Melting point: 129-131 °C(lit.)
Boiling point: 313 °C(lit.)
Density  1.059 g/mL at 25 °C(lit.)
refractive index  1.5369 (estimate)
storage temp.  Inert atmosphere,Room Temperature
solubility  soluble in Methanol
pka 8.28±0.18(Predicted)
form  Powder or Crystals
Specific Gravity 1.059
color  Off-white to beige to tan
CAS DataBase Reference 875-59-2(CAS DataBase Reference)

Safety information for 4'-HYDROXY-2'-METHYLACETOPHENONE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 4'-HYDROXY-2'-METHYLACETOPHENONE

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