4-Fluorophenylacetic acid

CAS NO.：405-50-5
Empirical Formula: C8H7FO2
Molecular Weight: 154.14
MDL number: MFCD00004343
EINECS: 206-972-4
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-31 13:32:20

What is 4-Fluorophenylacetic acid?

Chemical properties

white shiny crystalline powder or flakes

The Uses of 4-Fluorophenylacetic acid

4-Fluorophenylacetic acid is used as an intermediate in the production of fluorinated anesthetics.

Synthesis Reference(s)

Journal of the American Chemical Society, 78, p. 6037, 1956 DOI: 10.1021/ja01604a023

Purification Methods

Crystallise it from heptane, but it is best purified by distillation at high vacuum. [Bergmann et al. J Am Chem Soc 78 6037 1956, Beilstein 9 III 2261, 9 IV 1672.]

Properties of 4-Fluorophenylacetic acid

Melting point:	81-83 °C (lit.)
Boiling point:	164°C (2.25 torr)
Density	1.1850 (estimate)
Flash point:	>100°C
storage temp.	Sealed in dry,Room Temperature
form	Shiny Crystalline Powder or Flakes
pka	pK1:4.25 (25°C)
color	White
Water Solubility	Insoluble in water.
Merck	14,4177
BRN	972145
CAS DataBase Reference	405-50-5(CAS DataBase Reference)
NIST Chemistry Reference	Benzeneacetic acid, 4-fluoro-(405-50-5)
EPA Substance Registry System	Benzeneacetic acid, 4-fluoro- (405-50-5)

Safety information for 4-Fluorophenylacetic acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.