2,4-DICHLOROQUINOLINE
- CAS NO.:703-61-7
- Empirical Formula: C9H5Cl2N
- Molecular Weight: 198.05
- MDL number: MFCD00023939
- EINECS: 640-568-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 17:06:39
What is 2,4-DICHLOROQUINOLINE?
The Uses of 2,4-DICHLOROQUINOLINE
2,4-Dichloroquinoline is used in the synthesis of tRNA synthetase inhibitors with antibacterial activity against gram-positive bacteria. Also used in the preparation of arylquinolines displaying anthelmintic properties.
Synthesis
The synthesis of 2,4-dichloroquinoline is as follows:A suspension of quinoline-2,4-diol (150 g, 931 mmol) in POCl3 (975 mL, 10.4 mol) was stirred at reflux for 6 hr and the reaction mixture was concentrated. The residue was diluted with CHCl3 (500 mL) and the solution was poured into ice water. The aqueous layer was extracted with CHCl3 (three times). The combined organic layer was dried over MgSO4, filtrated, concentrated, and purified by flash chromatography (silica gel, 20% EtOAc in hexane) to give 2,4-dichloroquinoline (177 g, 96%) as a pale brown solid.
Properties of 2,4-DICHLOROQUINOLINE
Melting point: | 52-54 |
Boiling point: | 282°C(lit.) |
Density | 1.4178 (rough estimate) |
refractive index | 1.6610 (estimate) |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
solubility | Chloroform, Methanol |
form | Solid |
pka | -1.10±0.50(Predicted) |
color | White |
λmax | 305nm(MeOH)(lit.) |
CAS DataBase Reference | 703-61-7(CAS DataBase Reference) |
Safety information for 2,4-DICHLOROQUINOLINE
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 Skull and Crossbones Acute Toxicity GHS06 Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H301:Acute toxicity,oral H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2,4-DICHLOROQUINOLINE
InChIKey | QNBJYUUUYZVIJP-UHFFFAOYSA-N |
Abamectin manufacturer
Dr. Silviu Pharmachem Pvt., Ltd.
Dr R R Organics
New Products
4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
You may like
-
703-61-7 2,4-Dichloroquinoline 98%View Details
703-61-7 -
703-61-7 98%View Details
703-61-7 -
2,4-Dichloroquinoline 98%View Details
703-61-7 -
2,4-Dichloroquinoline 703-61-7 98%View Details
703-61-7 -
2,4-Dichloroquinoline CAS 703-61-7View Details
703-61-7 -
1823368-42-8 98%View Details
1823368-42-8 -
2-(3-(tert-butyl)phenoxy)-2-methylpropanoic acid 1307449-08-6 98%View Details
1307449-08-6 -
Lithium ClavulanateView Details
61177-44-4