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HomeProduct name list2,4-DICHLOROQUINOLINE

2,4-DICHLOROQUINOLINE

  • CAS NO.:703-61-7
  • Empirical Formula: C9H5Cl2N
  • Molecular Weight: 198.05
  • MDL number: MFCD00023939
  • EINECS: 640-568-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-06-08 17:06:39
2,4-DICHLOROQUINOLINE Structural

What is 2,4-DICHLOROQUINOLINE?

The Uses of 2,4-DICHLOROQUINOLINE

2,4-Dichloroquinoline is used in the synthesis of tRNA synthetase inhibitors with antibacterial activity against gram-positive bacteria. Also used in the preparation of arylquinolines displaying anthelmintic properties.

Synthesis

The synthesis of 2,4-dichloroquinoline is as follows:A suspension of quinoline-2,4-diol (150 g, 931 mmol) in POCl3 (975 mL, 10.4 mol) was stirred at reflux for 6 hr and the reaction mixture was concentrated. The residue was diluted with CHCl3 (500 mL) and the solution was poured into ice water. The aqueous layer was extracted with CHCl3 (three times). The combined organic layer was dried over MgSO4, filtrated, concentrated, and purified by flash chromatography (silica gel, 20% EtOAc in hexane) to give 2,4-dichloroquinoline (177 g, 96%) as a pale brown solid.  
synthesis of 2,4-DICHLOROQUINOLINE

Properties of 2,4-DICHLOROQUINOLINE

Melting point: 52-54
Boiling point: 282°C(lit.)
Density  1.4178 (rough estimate)
refractive index  1.6610 (estimate)
storage temp.  Keep in dark place,Sealed in dry,Room Temperature
solubility  Chloroform, Methanol
form  Solid
pka -1.10±0.50(Predicted)
color  White
λmax 305nm(MeOH)(lit.)
CAS DataBase Reference 703-61-7(CAS DataBase Reference)

Safety information for 2,4-DICHLOROQUINOLINE

Signal word Danger
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
ghs
Skull and Crossbones
Acute Toxicity
GHS06
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H301:Acute toxicity,oral
H315:Skin corrosion/irritation
H318:Serious eye damage/eye irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 2,4-DICHLOROQUINOLINE

InChIKey QNBJYUUUYZVIJP-UHFFFAOYSA-N

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