4-Chlorobenzhydrol
Synonym(s):4-Chlorobenzhydrol
- CAS NO.:119-56-2
- Empirical Formula: C13H11ClO
- Molecular Weight: 218.68
- MDL number: MFCD00004491
- EINECS: 204-333-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-01 18:09:03
What is 4-Chlorobenzhydrol?
Chemical properties
white crystalline powder
The Uses of 4-Chlorobenzhydrol
4-Chlorobenzhydrol was used as internal standard to measure the N-demethyl antipyrine metabolite in urine by gas chromatography-mass spectrometry. It was also used in the identification of the antihistamine cetirizine as a relevant cross-reactant for the carbamazepine-specific enzyme-linked immunosorbent assay .
Preparation
Preparation of 4-Chlorobenzhydrol(4-CB):
about 5.0g(0.023 mol) of 4-chloro benzophenone was dissolved in 15 mL of isopropyl alcohol (IPA) and heated to 50°C followed by the addition of 0.265g(0.007 mol) of sodium borohydride as a lot with the temperature maintained at 65°C for 2 h. The reaction mixture was distilled to expel isopropyl alcohol up to 90 %. The resulting solution was cooled and treated with dil HCl (5 mL of conc. HCl in 20 mL of water). Finally the reaction mass was extracted with 15 mL of toluene. The toluene extract was washed withwater to pH-7. The compound obtained in this step was taken to next step without isolation but aliquot sample was concentrated, isolated and checked for melting point (m.p. = 58-60°C).
Definition
ChEBI: P-Chlorobenzhydrol is a diarylmethane.
Properties of 4-Chlorobenzhydrol
Melting point: | 58-60 °C (lit.) |
Boiling point: | 150-151°C 2,6mm |
Density | 1.1178 (rough estimate) |
refractive index | 1.5260 (estimate) |
Flash point: | 150-151°C/2.6mm |
storage temp. | 2-8°C |
solubility | insoluble |
form | neat |
pka | 13.34±0.20(Predicted) |
color | White to Off-White |
Water Solubility | insoluble |
BRN | 2050235 |
CAS DataBase Reference | 119-56-2(CAS DataBase Reference) |
NIST Chemistry Reference | Benzenemethanol, 4-chloro-«alpha»-phenyl-(119-56-2) |
EPA Substance Registry System | Benzenemethanol, 4-chloro-.alpha.-phenyl- (119-56-2) |
Safety information for 4-Chlorobenzhydrol
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H412:Hazardous to the aquatic environment, long-term hazard |
Precautionary Statement Codes |
P273:Avoid release to the environment. P501:Dispose of contents/container to..… |
Computed Descriptors for 4-Chlorobenzhydrol
Abamectin manufacturer
KARPSCHEM LABORATORIES PVT. LTD.
Glyra Health Care Pvt Ltd
VAIKUNTH CHEMICAL PVT. LTD.
New Products
4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
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