2-(2-Hydroxyethyl)pyridine

Synonym(s):2-(2-Hydroxyethyl)pyridine;2-(2-Pyridyl)ethanol

CAS NO.：103-74-2
Empirical Formula: C7H9NO
Molecular Weight: 123.15
MDL number: MFCD00006364
EINECS: 203-140-2
SAFETY DATA SHEET (SDS)
Update Date: 2025-01-27 09:38:02

What is 2-(2-Hydroxyethyl)pyridine?

Chemical properties

clear yellow to brown liquid

The Uses of 2-(2-Hydroxyethyl)pyridine

2-(2-Hydroxyethyl)pyridine is a metabolite of the anti-vertigo drug Betahistine. It acts as a reagent for protection of the 5'-phosphate of nucleotides as 2-pyridylethyl (Pet) esters. It is used for carboxyl protection of amino acids. It is also used to cleave such groups as Boc and Fmoc, and also to hydrogenolysis. It was used to prepare mononuclear nickel(II) acetate.

The Uses of 2-(2-Hydroxyethyl)pyridine

2-Pyridineethanol is a metabolite of the anti-vertigo drug Betahistine (B324000).

General Description

2-(2-pyridyl)ethanol derivatives react with the aryl and alkenyl chlorides (palladium-catalyzed reactions) that result in the substitution of the chloro moieties with a 2-pyridylmethyl group.

Properties of 2-(2-Hydroxyethyl)pyridine

Melting point:	-8--7°C
Boiling point:	114-116 °C/9 mmHg (lit.)
Density	1.093 g/mL at 25 °C (lit.)
vapor pressure	1.16-14.1Pa at 25℃
refractive index	n20/D 1.537(lit.)
Flash point:	199 °F
storage temp.	Inert atmosphere,Room Temperature
solubility	Soluble in Chloroform (Slightly), Methanol (Slightly).
form	Liquid
pka	14.49±0.10(Predicted)
color	Clear yellow to brown
PH	8-9 (100g/l, H2O, 20℃)
Water Solubility	soluble
Sensitive	Hygroscopic
BRN	111205
CAS DataBase Reference	103-74-2(CAS DataBase Reference)
NIST Chemistry Reference	2-Pyridineethanol(103-74-2)
EPA Substance Registry System	2-Pyridineethanol (103-74-2)

Safety information for 2-(2-Hydroxyethyl)pyridine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P337+P313:IF eye irritation persists: Get medical advice/attention.