4-chloro-7-Methoxyquinoline-6-carboxaMide

CAS NO.：417721-36-9
Empirical Formula: C11H9ClN2O2
Molecular Weight: 236.65
MDL number: MFCD13192256
EINECS: 000-000-0
SAFETY DATA SHEET (SDS)
Update Date: 2024-12-26 17:28:21

What is 4-chloro-7-Methoxyquinoline-6-carboxaMide?

Description

4-chloro-7-Methoxyquinoline-6-carboxaMide is a pharmaceutical intermediate compound used in the preparation of Lenvatinib, an oral multi-receptor tyrosine kinase inhibitor approved by the FDA for the treatment of radioiodine-refractory differentiated thyroid cancer (DTC), unresectable (DTC), unresectable hepatocellular carcinoma (HCC), and advanced renal cell carcinoma (RCC).

Chemical properties

light yellow powder

The Uses of 4-chloro-7-Methoxyquinoline-6-carboxaMide

Pharmaceutical Intermediates. 4-chloro-7-Methoxyquinoline-6-carboxaMide is used as an intermediate for synthesizing Lenvatinibis.

Properties of 4-chloro-7-Methoxyquinoline-6-carboxaMide

Melting point:	>205°C (dec.)
Boiling point:	426.7±45.0 °C(Predicted)
Density	1.380±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	15.28±0.30(Predicted)
color	Off-White to Light Beige
InChI	InChI=1S/C11H9ClN2O2/c1-16-10-5-9-6(4-7(10)11(13)15)8(12)2-3-14-9/h2-5H,1H3,(H2,13,15)
CAS DataBase Reference	417721-36-9

Safety information for 4-chloro-7-Methoxyquinoline-6-carboxaMide

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.