4-Bromo-3-fluorotoluene

CAS NO.：452-74-4
Empirical Formula: C7H6BrF
Molecular Weight: 189.02
MDL number: MFCD00040940
EINECS: 629-423-4
SAFETY DATA SHEET (SDS)
Update Date: 2025-09-25 17:15:13

What is 4-Bromo-3-fluorotoluene?

Chemical properties

colorless to light yellow liqui

The Uses of 4-Bromo-3-fluorotoluene

4-Bromo-3-fluorotoluene is used in the synthesis of S-trityl-L-cysteine based inhibitors that show potent antitumor activity in lung cancer models. Chemical reagent for organic synthesis.

The Uses of 4-Bromo-3-fluorotoluene

4-Bromo-3-fluorotoluene may be used in the preparation of 1-(4-cyano-3- fluorobenzyl)-5-imidazolecarboxaldehyde and 1-bromo-4-bromomethyl-2-fluorobenzene.

General Description

4-Bromo-3-fluorotoluene (1-bromo-2-fluoro-4-methylbenzene) is an aryl fluorinated building block. Synthesis of 4-bromo-3-fluorotoluene from o-nitro-p-toluidine (Fast Red Base GL), via diazo reaction at high temperature, Sandmeyer reaction, reduction and Schiemann reaction has been reported. Its density and refractive index have been determined.

Properties of 4-Bromo-3-fluorotoluene

Boiling point:	95 °C/50 mmHg (lit.)
Density	1.494 g/mL at 25 °C (lit.)
refractive index	n20/D 1.53(lit.)
Flash point:	95 °F
storage temp.	Sealed in dry,Room Temperature
form	Liquid
color	Clear light yellow
Specific Gravity	1.494
BRN	2500154
CAS DataBase Reference	452-74-4(CAS DataBase Reference)

Safety information for 4-Bromo-3-fluorotoluene

Signal word	Warning
Pictogram(s)	Flame Flammables GHS02 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H226:Flammable liquids H227:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P240:Ground/bond container and receiving equipment. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. P403+P235:Store in a well-ventilated place. Keep cool. P501:Dispose of contents/container to..…