4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE
Synonym(s):GSK-3β Inhibitor I - CAS 327036-89-5 - Calbiochem;TDZD-8, 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
- CAS NO.:327036-89-5
- Empirical Formula: C10H10N2O2S
- Molecular Weight: 222.26
- MDL number: MFCD04973552
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-01 18:44:47
What is 4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE?
Chemical properties
White Solid
The Uses of 4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE
Glycogen Synthase Kinase-3? is a highly conserved ubiquitously expressed serine/threonine protein kinase involved in signal transduction cascades of multiple cellular processes. TDZD-8 is a thiadiazolidinone (TDZD) analogue that acts as a highly selectiv
The Uses of 4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE
TDZD-8 has been used to study the role of GSK-3 in maintaining MLL leukemia stem cell transcriptional program. TDZD-8 has also been used to analyze its effect on neural functions of the mouse olfactory bulb.
What are the applications of Application
GSK-3β Inhibitor I is a thiadiazolidinone analog that acts as a highly selective, non-ATP competitive inhibitor of GSK-3β
Definition
ChEBI: TDZD-8 is a member of the class of thiadiazolidines that is 1,2,4-thiadiazolidine-3,5-dione which is substituted by a methyl group at position 2 and by a benzyl group at position 4. It is a non-ATP competitive inhibitor of glycogen synthase kinase 3beta (GSK3beta). An experimental compound which was being developed for the potential treatment of Alzheimer's disease. It has a role as an EC 2.7.11.26 (tau-protein kinase) inhibitor, an apoptosis inducer, an antineoplastic agent, a neuroprotective agent and an anti-inflammatory agent. It is a thiadiazolidine and a member of benzenes.
General Description
A cell-permeable, thiadiazolidinone (TDZD) analog that acts as a highly selective, non-ATP-competitive inhibitor of GSK-3β (IC50 = 2 μM). Inhibits Flt-3 and PKC activities (IC50 = 673 nM and 1.4-5.5 μM, respectively). Does not significantly affect the activities of Cdk1/cyclin B, CK-II, PKA, or PKC (IC50 >100 μM). Shown to inhibit collagen- and thrombin-induced platelet aggregation.
Biological Activity
tdzd-8 is an inhibitor of glycogen synthase kinase-3β (gsk-3β) with ic50 value of 1.4μm [1].tdzd-8 is a potent inhibitor of gsk-3β. it is found to act as a noncompetitive inhibitor of atp binding. tdzd-8 is selective against gsk-3β over other protein kinases including pka, casein kinase ii and cyclin dependent kinase 1 (cdk-1/cyclin b). however, it is also reported that tdzd-8 can inhibit the protein kinase c isoforms pkcβi and pkcδ with ic50 values of 1.4μm and 1.1μm, respectively [1, 2].in cellular assay, tdzd-8 is found to decrease pdt-induced necrosis of neurons and decrease pdt-induced apoptosis of glial cells through inhibiting gsk-3β as well as pkc. besides that, tdzd-8 also has anti-leukemia activity in many primary human leukemia cells. it is probably due to its inhibition of pkc and flt3 [3].
Biochem/physiol Actions
Primary TargetGsk-3β
storage
Store at -20°C
References
[1] komandirov m a, knyazeva e a, fedorenko y p, et al. on the role of phosphatidylinositol 3-kinase, protein kinase b/akt, and glycogen synthase kinase-3β in photodynamic injury of crayfish neurons and glial cells. journal of molecular neuroscience, 2011, 45(2): 229-235.
[2] martinez a, alonso m, castro a, et al. first non-atp competitive glycogen synthase kinase 3 β (gsk-3β) inhibitors: thiadiazolidinones (tdzd) as potential drugs for the treatment of alzheimer's disease. journal of medicinal chemistry, 2002, 45(6): 1292-1299.
[3] guzman m l, li x, corbett c a, et al. rapid and selective death of leukemia stem and progenitor cells induced by the compound 4-benzyl, 2-methyl, 1, 2, 4-thiadiazolidine, 3, 5 dione (tdzd-8). blood, 2007, 110(13): 4436-4444.
Properties of 4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE
Melting point: | 63-64.4 °C |
Boiling point: | 335.5±35.0 °C(Predicted) |
Density | 1.375±0.06 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | DMSO: 18 mg/mL |
pka | -2.08±0.20(Predicted) |
form | needles |
color | white |
Safety information for 4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE
Signal word | Danger |
Pictogram(s) |
Health Hazard GHS08 |
GHS Hazard Statements |
H334:Sensitisation, respiratory |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P342+P311:IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
Computed Descriptors for 4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE
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