327036-89-5
Product Name:
4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE
Formula:
C10H10N2O2S
Synonyms:
GSK-3β Inhibitor I - CAS 327036-89-5 - Calbiochem;TDZD-8, 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
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SAFETY INFORMATION
Signal word | Danger |
---|---|
Pictogram(s) |
Health Hazard GHS08 |
GHS Hazard Statements |
H334:Sensitisation, respiratory |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P342+P311:IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
COMPUTED DESCRIPTORS
Molecular Weight | 222.27 g/mol |
---|---|
XLogP3 | 1.5 |
Hydrogen Bond Donor Count | 0 |
Hydrogen Bond Acceptor Count | 3 |
Rotatable Bond Count | 2 |
Exact Mass | 222.04629874 g/mol |
Monoisotopic Mass | 222.04629874 g/mol |
Topological Polar Surface Area | 65.9 Ų |
Heavy Atom Count | 15 |
Formal Charge | 0 |
Complexity | 277 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 0 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently-Bonded Unit Count | 1 |
Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
TDZD-8 is a member of the class of thiadiazolidines that is 1,2,4-thiadiazolidine-3,5-dione which is substituted by a methyl group at position 2 and by a benzyl group at position 4. It is a non-ATP competitive inhibitor of glycogen synthase kinase 3beta (GSK3beta). An experimental compound which was being developed for the potential treatment of Alzheimer's disease. It has a role as an EC 2.7.11.26 (tau-protein kinase) inhibitor, an apoptosis inducer, an antineoplastic agent, a neuroprotective agent and an anti-inflammatory agent. It is a thiadiazolidine and a member of benzenes.