4-Aminobenzophenone

Synonym(s):4-Aminophenyl phenyl ketone;4-Benzoylaniline

CAS NO.：1137-41-3
Empirical Formula: C13H11NO
Molecular Weight: 197.23
MDL number: MFCD00007895
EINECS: 214-506-6
SAFETY DATA SHEET (SDS)
Update Date: 2024-12-18 14:07:02

What is 4-Aminobenzophenone?

Chemical properties

YELLOW FINE CRYSTALLINE POWDER

The Uses of 4-Aminobenzophenone

4-Aminobenzophenone is associated with 4-benzoylpyridine and it is used as a frequency doubler for semiconductor lasers. It is used in the preparation of 1-[4-[N,N-bis(trimethylsilyl)amino]phenyl]-1-phenylethylene. It is used as a precursor to prepare 1,2,3-triazoles, pyrimidotriazoles, benzothiazole and pyrimidinone derivatives. It is involved in the formation of coordination complexes with chromium(III).

Synthesis Reference(s)

Tetrahedron Letters, 39, p. 1313, 1998 DOI: 10.1016/S0040-4039(97)10877-2

General Description

4-Aminobenzophenone (4-ABP) is the best derivative of benzophenone with 260 times higher second harmonic generation (SHG) efficiency than potassium dihydrogen phosphate (KDP), growth of high quality bulk crystal still remains a difficult task.

Safety Profile

Poison by intraperitoneal route. See also KETONES and AMINES. When heated to decomposition it emits toxic fumes of NOx,.

Purification Methods

Dissolve it in aqueous acetic acid, filter and precipitate it with ammonia. This process is repeated several times, then the amine is recrystallised from aqueous EtOH. [Beilstein 14 IV 248.]

Properties of 4-Aminobenzophenone

Melting point:	121-124 °C (lit.)
Boiling point:	246 °C (12.7517 mmHg)
Density	1.0957 (rough estimate)
refractive index	1.6050 (estimate)
Flash point:	245-247°C/22mm
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
pka	pK1: 2.15(+1) (25°C)
form	Fine Crystalline Powder
color	Yellow
Water Solubility	Soluble in cold water, alcohol and ether.
BRN	389292
CAS DataBase Reference	1137-41-3(CAS DataBase Reference)
EPA Substance Registry System	Methanone, (4-aminophenyl)phenyl- (1137-41-3)

Safety information for 4-Aminobenzophenone

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.