4-Amino-3,5-dichlorophenacylbromide
- CAS NO.：37148-47-3
- Empirical Formula: C8H6BrCl2NO
- Molecular Weight: 282.95
- MDL number: MFCD09743795
- EINECS: 253-367-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-09-23 15:54:53
What is 4-Amino-3,5-dichlorophenacylbromide?
Chemical properties
Yellow Solid
The Uses of 4-Amino-3,5-dichlorophenacylbromide
1-(4-Amino-3,5-dichlorophenyl)-2-bromoethanone Hydrobromide is an intermediate in synthesizing Clenproperol-d7 (C573002). A labelled related drug of Clenbuterol (C569998), a β-agonist which can be used as a growth promoter in farm animals.
The Uses of 4-Amino-3,5-dichlorophenacylbromide
4-Amino-3,5-dichloro-alpha-bromoacetophenone is an impurity reference for Clenbuterol and can be used as a reference substance to analyze drug quality. It is widely used in organic synthesis and drug production.
Preparation
Dissolve 4-amino-3, 5-dichloroacetophenone in chloroform and heat to 65°C. Add bromine dropwise with stirring, stir for a few minutes after adding, then add ethanol and stir. Freeze, filter out the crystals, wash with chloroform, and dry at low temperature to obtain finished products.
Properties of 4-Amino-3,5-dichlorophenacylbromide
| Melting point: | 142-1450C |
| Boiling point: | 396.4±42.0 °C(Predicted) |
| Density | 1.764±0.06 g/cm3(Predicted) |
| storage temp. | -20°C Freezer, Under Inert Atmosphere |
| solubility | DMSO (Slightly), Ethyl Acetate (Slightly) |
| form | Solid |
| pka | -2.21±0.10(Predicted) |
| color | Off-White to Yellow |
| Stability: | Moisture Sensitive |
| InChI | InChI=1S/C8H6BrCl2NO/c9-3-7(13)4-1-5(10)8(12)6(11)2-4/h1-2H,3,12H2 |
| CAS DataBase Reference | 37148-47-3 |
Safety information for 4-Amino-3,5-dichlorophenacylbromide
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-Amino-3,5-dichlorophenacylbromide
| InChIKey | ATKJJUFAWYSFID-UHFFFAOYSA-N |
| SMILES | C(=O)(C1=CC(Cl)=C(N)C(Cl)=C1)CBr |
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