4-Amino-3,5-dichloroacetophenone
Synonym(s):1-(4-Amino-3,5-dichlorophenyl)-ethanone;3,5-Dichloro-4-aminoacetophenone
- CAS NO.:37148-48-4
- Empirical Formula: C8H7Cl2NO
- Molecular Weight: 204.05
- MDL number: MFCD00238535
- EINECS: 253-368-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-09-23 15:54:53
What is 4-Amino-3,5-dichloroacetophenone?
Chemical properties
4-Amino-3,5-dichloroacetophenone is a white to light yellow crystal powder. Insoluble in cold water, slightly soluble in hot water.
The Uses of 4-Amino-3,5-dichloroacetophenone
4-Amino-3,5-dichloroacetophenone is used to synthesize the drug Clenbuterol. Clenbuterol is a steroid-like chemical that was initially developed to treat asthma in horses, working by relaxing the airways in the animals'lungs.
What are the applications of Application
1-(4-Amino-3,5-dichloro-phenyl)-2-ethanone is An aromatic amine
Preparation
4-Amino-3,5-dichloroacetophenone was synthesized by chlorination of 4-aminoacetophenone. Add 4-aminoacetophenone and acetic acid (80%) into the reaction pot, stir and dissolve, quickly add chlorine-containing glacial acetic acid solution, the temperature of the addition is 5°C. After the addition is completed, immediately put into ice water to precipitate, filter, and wash with water to obtain the crude product. Recrystallize with ethanol to obtain the finished product of 4-Amino-3,5-dichloroacetophenone.
What are the applications of Application
4-Amino-3,5-dichloroacetophenone is a compound useful in organic synthesis.
What are the applications of Application
4-Amino-3,5-dichloroacetophenone has active chemical properties and has been widely used in industrial chemistry, agricultural chemistry, and pharmaceutical chemistry. As a selective oxidant and green coupling reagent, it participates in a variety of oxidation reactions, rearrangement reactions, and amination reactions. In industry, it can also be used as a raw material for the synthesis of drugs, disinfectants, dyes, food seasonings, adhesives, explosives, etc.
Properties of 4-Amino-3,5-dichloroacetophenone
Melting point: | 162-166 °C(lit.) |
Boiling point: | 351.5±42.0 °C(Predicted) |
Density | 1.2748 (rough estimate) |
refractive index | 1.5500 (estimate) |
storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
solubility | DMSO (Slightly), Methanol (Slightly) |
pka | -1.72±0.10(Predicted) |
form | Solid |
color | Light Tan to Brown |
InChI | InChI=1S/C8H7Cl2NO/c1-4(12)5-2-6(9)8(11)7(10)3-5/h2-3H,11H2,1H3 |
CAS DataBase Reference | 37148-48-4(CAS DataBase Reference) |
Safety information for 4-Amino-3,5-dichloroacetophenone
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-Amino-3,5-dichloroacetophenone
InChIKey | JLPKZJDZXIKSCP-UHFFFAOYSA-N |
SMILES | C(=O)(C1=CC(Cl)=C(N)C(Cl)=C1)C |
Abamectin manufacturer
BASR Fine Chemicals Pvt. Ltd.
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