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HomeProduct name list4-Amino-3,5-dichloroacetophenone

4-Amino-3,5-dichloroacetophenone

Synonym(s):1-(4-Amino-3,5-dichlorophenyl)-ethanone;3,5-Dichloro-4-aminoacetophenone

  • CAS NO.:37148-48-4
  • Empirical Formula: C8H7Cl2NO
  • Molecular Weight: 204.05
  • MDL number: MFCD00238535
  • EINECS: 253-368-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-09-23 15:54:53
4-Amino-3,5-dichloroacetophenone Structural

What is 4-Amino-3,5-dichloroacetophenone?

Chemical properties

4-Amino-3,5-dichloroacetophenone is a white to light yellow crystal powder. Insoluble in cold water, slightly soluble in hot water.

The Uses of 4-Amino-3,5-dichloroacetophenone

4-Amino-3,5-dichloroacetophenone is used to synthesize the drug Clenbuterol. Clenbuterol is a steroid-like chemical that was initially developed to treat asthma in horses, working by relaxing the airways in the animals'lungs.

What are the applications of Application

1-(4-Amino-3,5-dichloro-phenyl)-2-ethanone is An aromatic amine

Preparation

4-Amino-3,5-dichloroacetophenone was synthesized by chlorination of 4-aminoacetophenone. Add 4-aminoacetophenone and acetic acid (80%) into the reaction pot, stir and dissolve, quickly add chlorine-containing glacial acetic acid solution, the temperature of the addition is 5°C. After the addition is completed, immediately put into ice water to precipitate, filter, and wash with water to obtain the crude product. Recrystallize with ethanol to obtain the finished product of 4-Amino-3,5-dichloroacetophenone.

What are the applications of Application

4-Amino-3,5-dichloroacetophenone is a compound useful in organic synthesis.

What are the applications of Application

4-Amino-3,5-dichloroacetophenone has active chemical properties and has been widely used in industrial chemistry, agricultural chemistry, and pharmaceutical chemistry. As a selective oxidant and green coupling reagent, it participates in a variety of oxidation reactions, rearrangement reactions, and amination reactions. In industry, it can also be used as a raw material for the synthesis of drugs, disinfectants, dyes, food seasonings, adhesives, explosives, etc.

Properties of 4-Amino-3,5-dichloroacetophenone

Melting point: 162-166 °C(lit.)
Boiling point: 351.5±42.0 °C(Predicted)
Density  1.2748 (rough estimate)
refractive index  1.5500 (estimate)
storage temp.  Keep in dark place,Inert atmosphere,Room temperature
solubility  DMSO (Slightly), Methanol (Slightly)
pka -1.72±0.10(Predicted)
form  Solid
color  Light Tan to Brown
InChI InChI=1S/C8H7Cl2NO/c1-4(12)5-2-6(9)8(11)7(10)3-5/h2-3H,11H2,1H3
CAS DataBase Reference 37148-48-4(CAS DataBase Reference)

Safety information for 4-Amino-3,5-dichloroacetophenone

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 4-Amino-3,5-dichloroacetophenone

InChIKey JLPKZJDZXIKSCP-UHFFFAOYSA-N
SMILES C(=O)(C1=CC(Cl)=C(N)C(Cl)=C1)C

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