4-Amino-3-hydrazino-1,2,4-triazol-5-thiol

Synonym(s):4-Amino-3-hydrazino-5-mercapto-1,2,4-triazole;4-Amino-5-hydrazino-1,2,4-triazole-3-thiol

CAS NO.：1750-12-5
Empirical Formula: C2H6N6S
Molecular Weight: 146.17
MDL number: MFCD00003098
EINECS: 217-135-8
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-21 22:41:43

4-Amino-3-hydrazino-1,2,4-triazol-5-thiol Structural

What is 4-Amino-3-hydrazino-1,2,4-triazol-5-thiol?

Chemical properties

Beige solid

The Uses of 4-Amino-3-hydrazino-1,2,4-triazol-5-thiol

A reagent for the determination of aldehydes and other reactive chemicals

The Uses of 4-Amino-3-hydrazino-1,2,4-triazol-5-thiol

4-Amino-3-hydrazino-5-mercapto-1,2,4-triazole is a reagent used in the determination of aldehydes and other reactive chemicals.was used in purpald assay for determination of bacterial polysaccharides containing substituted or unsubstituted glycol in residues such as glycerol, ribitol, arabinitol, furanosyl galactose and sialic acid. It was used as chromogen during the determination of catalase activity in small tissue samples. It was used as reagent in determination of formaldehyde. It was used for derivatization of neutral monosaccharides during HPLC.

The Uses of 4-Amino-3-hydrazino-1,2,4-triazol-5-thiol

Purpald^? was used in purpald assay for determination of bacterial polysaccharides containing substituted or unsubstituted glycol in residues such as glycerol, ribitol, arabinitol, furanosyl galactose and sialic acid.
It was used as chromogen during the determination of catalase activity in small tissue samples.
It was used as reagent in determination of formaldehyde.
It was used for derivatization of neutral monosaccharides during HPLC.

What are the applications of Application

4-Amino-3-hydrazino-5-mercapto-1,2,4-triazole is a reagent used in the determination of aldehydes and other reactive chemicals

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 26, p. 355, 1989 DOI: 10.1002/jhet.5570260216

Purification Methods

Recrystallise Purpald from H2O (0.6g in 300-400mL). The benzylidene derivative has m 245-246o(dec) from i-PrOH [Hoggarth J Chem Soc 4817 1952, Dickinson & Jacobson J Chem Soc, Perkin Trans I 975 1975.[Beilstein 26 III/IV 547.]

Properties of 4-Amino-3-hydrazino-1,2,4-triazol-5-thiol

Melting point:	228-230 °C (dec.)(lit.)
Boiling point:	275.0±23.0 °C(Predicted)
Density	2.31±0.1 g/cm3(Predicted)
storage temp.	0-6°C
solubility	Soluble in Dimethyl sulfoxide. (DMSO)
form	powder to crystal
pka	8.52±0.20(Predicted)
color	White to Almost white
BRN	134867
Stability:	Light Sensitive
CAS DataBase Reference	1750-12-5(CAS DataBase Reference)
EPA Substance Registry System	1,2,4-Triazolidin-3-one, 4-amino-5-thioxo-, hydrazone (1750-12-5)

Safety information for 4-Amino-3-hydrazino-1,2,4-triazol-5-thiol

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02
GHS Hazard Statements	H228:Flammable solids
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P240:Ground/bond container and receiving equipment. P241:Use explosion-proof electrical/ventilating/lighting/…/equipment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P370+P378:In case of fire: Use … for extinction.