4-Amino-1-Boc-piperidine
Synonym(s):tert-Butyl 4-amino-1-piperidinecarboxylate;1-Boc-4-piperidinamine
- CAS NO.:87120-72-7
- Empirical Formula: C10H20N2O2
- Molecular Weight: 200.28
- MDL number: MFCD01076201
- EINECS: 1312995-182-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-30 19:23:35
What is 4-Amino-1-Boc-piperidine?
Chemical properties
white to light yellow crystal powder
The Uses of 4-Amino-1-Boc-piperidine
4-Amino-1-Boc-piperidine is a chemical reagent used in the preparation of pharmaceutical compounds. Used in the synthesis of bromodomain inhibitors as well as HepG2 cell cycle inhibitors used in anti-tumor therapy. Also employed in a microwave-assisted solid-phase synthesis of N-substituted piperidines via direct annulation of primary amines with resin-bound dimesylates.
The Uses of 4-Amino-1-Boc-piperidine
4-Amino-1-Boc-piperidine is a potent inhibitor of the CCR5 receptor. It is an x-ray crystal structure with a hydroxide solution that inhibits the growth of cancer cells. The inhibitor binding site for 4-Amino-1-Boc-piperidine was determined to be the CCR5 receptor, which is located on the surface of hematopoietic cells. The compound has been shown to inhibit human T lymphocyte proliferation in vitro and inhibit HIV replication in infected patients. 4-Amino-1-Boc-piperidine is able to inhibit the growth of cancer cells by blocking the production of cytokines, such as interleukin 2, that are needed for cell division and growth.
What are the applications of Application
4-Amino-1-Boc-piperidine is a pharmaceutical intermediate is applied in the treatment of anti-tumor and other drugs. It is an important fine chemical intermediate and has a wide range of uses in the pharmaceutical industry.
Properties of 4-Amino-1-Boc-piperidine
Melting point: | 50°C |
Boiling point: | 80/0.037mm |
Density | 1.041±0.06 g/cm3(Predicted) |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
form | Crystalline Powder, Crystals and/or Chunks |
pka | 10.10±0.20(Predicted) |
color | White to pale yellow to beige |
Water Solubility | Insoluble in water. |
Sensitive | Air Sensitive |
InChI | InChI=1S/C10H20N2O2/c1-10(2,3)14-9(13)12-6-4-8(11)5-7-12/h8H,4-7,11H2,1-3H3 |
CAS DataBase Reference | 87120-72-7(CAS DataBase Reference) |
Safety information for 4-Amino-1-Boc-piperidine
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. |
Computed Descriptors for 4-Amino-1-Boc-piperidine
InChIKey | LZRDHSFPLUWYAX-UHFFFAOYSA-N |
SMILES | N1(C(OC(C)(C)C)=O)CCC(N)CC1 |
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