4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime
Synonym(s):4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime
- CAS NO.:55224-94-7
- Empirical Formula: C11H12ClNO
- Molecular Weight: 209.67
- MDL number: MFCD00102250
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 15:53:33
What is 4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime?
Description
AP-
The Uses of 4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime
AP-18 is a channel blocker that inhibits TRPA1.
The Uses of 4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime
AP-18 is a selective TRPA1 channel blocker. AP-18 blocks the transient receptor potential ankyrin 1 receptors and can reduce chronic pain associated with arthritis. AP-18 reduces cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation. AP-18 reverses CFA-induced mechanical hyperalgesia in mice
What are the applications of Application
AP-18 is AP-18 is a novel and effective TRPA1 channel blocker
Biological Activity
Reversible TRPA1 channel blocker (IC 50 values are 3.1 and 4.5 μ M at human and mouse TRPA1 respectively). Blocks cinnameldehyde-induced but not capsaicin-induced nociception and reverses mechanical hyperalgesia in vivo . Also blocks TRPA1 pore dilation (IC 50 = 10.3 μM for the inhibition of Yo-Pro uptake).
Biochem/physiol Actions
AP-18 is a selective TRPA1 channel blocker. Transient receptor potential A1 (TRPA1) plays a central role for chemical sensing in the pain pathway. AP-18 is a novel TRPA1 channel blocker. It reduces cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation demonstrating selectivity vs. TRPV11. AP-18 reverses CFA-induced mechanical hyperalgesia in mice.
in vivo
ap-18 blocks the transient receptor potential ankyrin 1 receptors and can reduce chronic pain associated with arthritis. this product is also capable to induce cinnamaldehyde-induced nociception and to block cold- and mustard oil-induced activation of mouse trpa1 but not capsaicin-induced activation 2. in addition, ap18 treatment reversed cfa-induced mechanical hyperalgesia in mice 2. thus, trpa1 is essential for sensitization of nociception.
storage
+4°C
References
References”Citations:
Properties of 4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime
storage temp. | 2-8°C |
solubility | DMSO: >10mg/mL |
form | solid |
color | white to off-white |
Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. |
Safety information for 4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P501:Dispose of contents/container to..… |
Computed Descriptors for 4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime
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