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HomeProduct name list4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime

4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime

Synonym(s):4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime

4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime Structural

What is 4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime?

Description

AP-18 is a channel blocker which reversibly inhibits TRPA1 (IC50s = 3.1 and 4.5 μM, human and mouse, respectively). It has minimal effect on TRPV1-4 or TRPM8. AP-18 has been used to study TRPA1 signaling in mice and rats as well as in vitro.

The Uses of 4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime

AP-18 is a channel blocker that inhibits TRPA1.

The Uses of 4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime

AP-18 is a selective TRPA1 channel blocker. AP-18 blocks the transient receptor potential ankyrin 1 receptors and can reduce chronic pain associated with arthritis. AP-18 reduces cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation. AP-18 reverses CFA-induced mechanical hyperalgesia in mice

What are the applications of Application

AP-18 is AP-18 is a novel and effective TRPA1 channel blocker

Biological Activity

Reversible TRPA1 channel blocker (IC 50 values are 3.1 and 4.5 μ M at human and mouse TRPA1 respectively). Blocks cinnameldehyde-induced but not capsaicin-induced nociception and reverses mechanical hyperalgesia in vivo . Also blocks TRPA1 pore dilation (IC 50 = 10.3 μM for the inhibition of Yo-Pro uptake).

Biochem/physiol Actions

AP-18 is a selective TRPA1 channel blocker. Transient receptor potential A1 (TRPA1) plays a central role for chemical sensing in the pain pathway. AP-18 is a novel TRPA1 channel blocker. It reduces cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation demonstrating selectivity vs. TRPV11. AP-18 reverses CFA-induced mechanical hyperalgesia in mice.

in vivo

ap-18 blocks the transient receptor potential ankyrin 1 receptors and can reduce chronic pain associated with arthritis. this product is also capable to induce cinnamaldehyde-induced nociception and to block cold- and mustard oil-induced activation of mouse trpa1 but not capsaicin-induced activation 2. in addition, ap18 treatment reversed cfa-induced mechanical hyperalgesia in mice 2. thus, trpa1 is essential for sensitization of nociception.

storage

+4°C

References

References”Citations:

Properties of 4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime

storage temp.  2-8°C
solubility  DMSO: >10mg/mL
form  solid
color  white to off-white
Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.

Safety information for 4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501:Dispose of contents/container to..…

Computed Descriptors for 4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime

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