4-[[4-(1H-benzimidazol-2-yl)phenyl]amino]-4-keto-butyric acid

CAS NO.：27031-00-1
Empirical Formula: C17H15N3O3
Molecular Weight: 309.32
MDL number: MFCD00395378
Update Date: 2024-11-20 11:41:24

What is 4-[[4-(1H-benzimidazol-2-yl)phenyl]amino]-4-keto-butyric acid?

Description

iGP-1 (27031-00-1) is a potent and cell permeable inhibitor of mitochondrial glycerol-3-phosphate dehydrogenase (mGPDH), IC50=6.3 μM, that is selective over the cytosolic enzyme1. It does not block pyruvate uptake into cells or mitochondria and has no direct effect on glycolysis in synaptosomes. This novel inhibitor is a unique tool which may be used to investigate the role of glycerol-3-phosphate metabolism in isolated and intact systems.1

References

1) Orr?et al.?(2014),?Novel inhibitors of mitochondrial sn-glycerol 3-phosphate dehydrogenase; PLoS One,?9?e89938

Properties of 4-[[4-(1H-benzimidazol-2-yl)phenyl]amino]-4-keto-butyric acid

Density	1.398±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	Soluble in DMSO (up to 50 mg/ml).
pka	4.48±0.10(Predicted)
form	solid
color	Beige
Stability:	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

Safety information for 4-[[4-(1H-benzimidazol-2-yl)phenyl]amino]-4-keto-butyric acid

Computed Descriptors for 4-[[4-(1H-benzimidazol-2-yl)phenyl]amino]-4-keto-butyric acid

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