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HomeProduct name list4-(Pyridin-3-yl)pyrimidin-2-amine

4-(Pyridin-3-yl)pyrimidin-2-amine

  • CAS NO.:66521-66-2
  • Empirical Formula: C9H8N4
  • Molecular Weight: 172.19
  • MDL number: MFCD01317832
  • EINECS: 1312995-182-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-13 11:39:26
4-(Pyridin-3-yl)pyrimidin-2-amine Structural

What is 4-(Pyridin-3-yl)pyrimidin-2-amine?

Chemical properties

White to off-white or brown solid.

The Uses of 4-(Pyridin-3-yl)pyrimidin-2-amine

Intermediate in the preparation of Nilotinib.

Synthesis

3-(Dimethylamino)-1-(pyridine-3-yl) prop-2-en-1-one (15.4 g, 0.088 mol), guanidine nitrate (10.7 g, 0.088 mol), and sodium hydroxide (3.5 g, 0.088 mol) were dissolved in n-butanol (120 mL). The mixture was heated to reflux with stirring and maintained for 16 hours. The reaction mixture was then cooled to room temperature. The solid was collected and washed with water (400 mL). The desired product was dried under vacuum for three days, and 12.7 g of yellow crystals of 4-(Pyridin-3-yl)pyrimidin-2-amine was obtained (yield: 85 %).

Properties of 4-(Pyridin-3-yl)pyrimidin-2-amine

Melting point: 189-191 °C
Boiling point: 439.9±37.0 °C(Predicted)
Density  1.259±0.06 g/cm3(Predicted)
storage temp.  under inert gas (nitrogen or Argon) at 2–8 °C
solubility  DMSO (Slightly), Methanol (Slightly)
form  Solid
pka 2.76±0.10(Predicted)
color  Off-White to Pale Yellow
InChI InChI=1S/C9H8N4/c10-9-12-5-3-8(13-9)7-2-1-4-11-6-7/h1-6H,(H2,10,12,13)

Safety information for 4-(Pyridin-3-yl)pyrimidin-2-amine

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313:IF SKIN irritation occurs: Get medical advice/attention.
P337+P313:IF eye irritation persists: Get medical advice/attention.

Computed Descriptors for 4-(Pyridin-3-yl)pyrimidin-2-amine

InChIKey LQHQKYWYKPLKCH-UHFFFAOYSA-N
SMILES C1(N)=NC=CC(C2=CC=CN=C2)=N1

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