4-(Pyridin-3-yl)pyrimidin-2-amine
- CAS NO.:66521-66-2
- Empirical Formula: C9H8N4
- Molecular Weight: 172.19
- MDL number: MFCD01317832
- EINECS: 1312995-182-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-13 11:39:26
What is 4-(Pyridin-3-yl)pyrimidin-2-amine?
Chemical properties
White to off-white or brown solid.
The Uses of 4-(Pyridin-3-yl)pyrimidin-2-amine
Intermediate in the preparation of Nilotinib.
Synthesis
3-(Dimethylamino)-1-(pyridine-3-yl) prop-2-en-1-one (15.4 g, 0.088 mol), guanidine nitrate (10.7 g, 0.088 mol), and sodium hydroxide (3.5 g, 0.088 mol) were dissolved in n-butanol (120 mL). The mixture was heated to reflux with stirring and maintained for 16 hours. The reaction mixture was then cooled to room temperature. The solid was collected and washed with water (400 mL). The desired product was dried under vacuum for three days, and 12.7 g of yellow crystals of 4-(Pyridin-3-yl)pyrimidin-2-amine was obtained (yield: 85 %).
Properties of 4-(Pyridin-3-yl)pyrimidin-2-amine
Melting point: | 189-191 °C |
Boiling point: | 439.9±37.0 °C(Predicted) |
Density | 1.259±0.06 g/cm3(Predicted) |
storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | Solid |
pka | 2.76±0.10(Predicted) |
color | Off-White to Pale Yellow |
InChI | InChI=1S/C9H8N4/c10-9-12-5-3-8(13-9)7-2-1-4-11-6-7/h1-6H,(H2,10,12,13) |
Safety information for 4-(Pyridin-3-yl)pyrimidin-2-amine
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for 4-(Pyridin-3-yl)pyrimidin-2-amine
InChIKey | LQHQKYWYKPLKCH-UHFFFAOYSA-N |
SMILES | C1(N)=NC=CC(C2=CC=CN=C2)=N1 |
Abamectin manufacturer
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product: 66521-66-2 4-(3-Pyridinyl)-2-aminopyrimidine 98%
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